AI Article Synopsis
- Biomolecular condensates are formed through weak multivalent interactions and polymerization, but the role of polymerization in this process is not well understood.
- In this study, the researchers discovered that the condensates of the protein SRFR1 in lateral root cap cells are crucial for proper primary root development, with its N-terminal domain being essential for this process.
- They also found that certain disordered proteins, called dehydrins, can replace a part of SRFR1, which helped identify key functional elements within the protein and led to potential strategies for enhancing plant growth and resilience.
Article Abstract
Formation of biomolecular condensates can be driven by weak multivalent interactions and emergent polymerization. However, the mechanism of polymerization-mediated condensate formation is less studied. We found lateral root cap cell (LRC)-specific SUPPRESSOR OF RPS4-RLD1 (SRFR1) condensates fine-tune primary root development. Polymerization of the SRFR1 N-terminal domain is required for both LRC condensate formation and optimal root growth. Surprisingly, the first intrinsically disordered region (IDR1) of SRFR1 can be functionally substituted by a specific group of intrinsically disordered proteins known as dehydrins. This finding facilitated the identification of functional segments in the IDR1 of SRFR1, a generalizable strategy to decode unknown IDRs. With this functional information we further improved root growth by modifying the SRFR1 condensation module, providing a strategy to improve plant growth and resilience.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11014531 | PMC |
| http://dx.doi.org/10.1101/2024.04.02.587845 | DOI Listing |
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