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Background: Positrons Emission Tomography associated with Computed Tomography - PET/CT using the 18F-fluorodeoxyglucose is a well-established exam for the context of dementia evaluation. However, FDG PET is a method still unavailable in most centers and diagnostic accuracy depends on the development of a flowchart that involves proper indication by clinicians and specialized evaluation by nuclear medicine specialists. Our study aims to investigate the indications of FDG PET in the differential diagnosis of dementia in a single center; secondarily, to evaluate how this method aided the diagnostic process.
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Alzheimers Dement
December 2024
Alzheimer's Disease & Brain Health, Eisai Inc., Nutley, NJ, USA.
Background: This study describes the total healthcare costs integrating direct, indirect, and intangible or emotional cost components across the severity stages of Alzheimer's disease (AD) in US.
Method: Utilizing Health and Retirement Study (HRS) data (1994-2018), a bi-annual US national survey of older adults, we assessed out-of-pocket and indirect costs, including unpaid caregiving services, missed workdays, and early retirement. HRS, analyzed with sampling weights, provided a representative US national sample.
Biomarkers.
Alzheimers Dement
December 2024
University of Michigan School of Public Health, Ann Arbor, MI, USA.
Background: Blood-based biomarker testing (BBT) for Alzheimer's disease (AD) to detect amyloid-beta and tau is becoming part of dementia care, with likely future clinical use in asymptomatic populations. Little is known about older adults' awareness of BBT or their perceptions of its potential benefits, risks, and limitations.
Method: We analyzed data from the March 2023 fielding of the University of Michigan National Poll on Healthy Aging, a nationally representative web and telephone survey of community-dwelling older U.
Background: Normal cognitive function is supported by the neuromodulatory mechanisms of the cholinergic system. In Parkinson's disease (PD), histological and molecular imaging evidence suggests disruption to cholinergic circuitry is associated with progression to Parkinson's disease dementia (PDD). The primary source of cortical cholinergic input is the Ch4 region of the basal forebrain.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia.
Background: As an extension of the central nervous system (CNS), the retina shares many similarities with the brain and can manifest signs of various neurological diseases, including Alzheimer's disease (AD). This study investigates the spectral features of the retina to develop a classification model for the differentiation of individuals with elevated brain amyloid levels.
Method: Participants (n=66) with varying brain Aβ levels, as determined by brain imaging, were non-invasively imaged using a hyperspectral retinal camera at wavelengths of 450 to 905 nm.
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