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Current Progress in the Development of mRNA Vaccines Against Bacterial Infections.
Int J Mol Sci
December 2024
Translational Medicine Research Center, Sirius University of Science and Technology, Sochi 354340, Russia.
Bacterial infections have accompanied humanity for centuries. The discovery of the first antibiotics and the subsequent golden era of their discovery temporarily shifted the balance in this confrontation to the side of humans. Nevertheless, the excessive and improper use of antibacterial drugs and the evolution of bacteria has gotten the better of humans again.
View Article and Find Full Text PDFWedge Resection and Nail Groove Reconstruction With Hanging Thread Knot in the Treatment of Onychocryptosis.
J Cosmet Dermatol
January 2025
Department of Dermatology, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
Background: Onychocryptosis is characterized by the nail plate penetrating the lateral nail fold, resulting in varying degrees of infection and deformity. Standardized treatment protocols for onychocryptosis, particularly in Stages IIb, III, and IV, have not been universally established, highlighting the urgent need for the development of effective interventions.
Objective: To evaluate the effectiveness and safety of wedge resection and nail groove reconstruction using the hanging thread knot for the treatment of onychocryptosis.
Treatment of Acute Sore Throat in Malaysia: A Consensus of Multidisciplinary Recommendations Using Modified Delphi Methodology.
Infect Drug Resist
September 2024
Centre for Medical Education, Cardiff University, Cardiff, UK.
Article Synopsis
- The use of antibiotics for treating acute sore throats is linked to antimicrobial resistance (AMR), prompting a need for better diagnostic tools and reduced prescriptions to improve patient outcomes.
- A panel of experts developed 10 consensus statements on managing sore throats, emphasizing the issues with improper antibiotic use, especially in viral cases, and recommending non-antibiotic pain relief methods.
- The McIsaac score and point-of-care testing for group A strep can help guide appropriate antibiotic use, highlighting symptomatic treatment as the primary focus for effective management.
Hypothalamus-pituitary-adrenal axis (HPA axis) suppression with inappropriate use of steroids in recalcitrant dermatophytosis - A cross-sectional study.
J Family Med Prim Care
May 2024
Department of Dermatology, AIIMS Rishikesh, Virbhadra Road, Rishikesh, Uttarakhand, India.
Background: Improper use of over-the-counter (OTC) steroid medication has been linked to recalcitrant dermatophytosis. There is proven evidence of HPA axis suppression by the use of long-term oral steroids. This study aims to determine the prevalence and pattern of inappropriate OTC steroid use and its effects on the hypothalamus-pituitary-adrenal (HPA) axis in adults with recalcitrant dermatophytosis.
View Article and Find Full Text PDFTopical Steroid Damaged Face - A Dermascopic Analysis.
J Pharm Bioallied Sci
April 2024
Department of Dermatology, Venerelogy and Leprosy, Datta Meghe Institute of Medical, Sciences, DMIHER, Sawangi (Meghe),Wardha, Maharashtra, India.
Background And Objectives: Dermoscopy particularly could be helpful in patients with steroid damaged face to assess and look for the damage caused by the steroid creams as also in cases where the patient provides improper history.
Materials And Methods: Patients attending to dermatology OPD with suspected/diagnosed TSDF between the ages of 18 and 60 years were enrolled and assessed on the basis of age, gender, residence, duration, potency, brand of application topical steroid creams, clinical and dermoscopic features.
Results: Majority abusing the topical steroid creams were females (n-14) with mean age with SD of 34 ± 11 and were from rural areas (57.
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