Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf.

J Vet Diagn Invest

School of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, NE, USA.

Published: July 2024

Distinct solitary dermal nodules, either covered by an alopecic, or sometimes ulcerated, epidermis, were noticed on the head of a stillborn Holstein calf. The head was submitted for autopsy, and the nodules were found to consist of homogeneous, diffuse pale-yellow, soft-tissue masses with distinct margins that elevated the epidermis above the adjacent skin. Histologically, the dermal nodules were well-delineated on the deep margin approaching the cutaneous muscle and consisted of perivascular neoplastic infiltrates of round cells that in some places coalesced into sheets that extended into the dermis and subcutis. Neoplastic cells separated adnexa and collagen. Immunohistochemistry revealed intense tumor cell expression of vimentin, Iba1, E-cadherin, and CD204; expression of CD18 was faint. The masses were diagnosed as Langerhans cell histiocytosis. Congenital cutaneous Langerhans cell histiocytosis has not been reported previously in cattle, to our knowledge, and should be included in the differential diagnosis of congenital nodular skin lesions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185123PMC
http://dx.doi.org/10.1177/10406387241245778DOI Listing

Publication Analysis

Top Keywords

langerhans cell
12
cell histiocytosis
12
cutaneous langerhans
8
holstein calf
8
dermal nodules
8
congenital localized
4
localized cutaneous
4
cell
4
histiocytosis holstein
4
calf distinct
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!