AI Article Synopsis
- Scedosporium apiospermum is a rare fungal pathogen that typically affects immunocompromised individuals and is associated with poor outcomes.
- A 37-year-old woman developed multiple lesions in her lungs, brain, and eyes after a near drowning incident, leading to confirmed S. apiospermum infection through advanced genomic sequencing.
- Despite treatment with voriconazole, the patient experienced significant improvement but unfortunately lost vision in one eye due to a delayed diagnosis, highlighting the need for prompt recognition and intervention even in otherwise healthy individuals.
Article Abstract
Background: Scedosporium apiospermum (S. apiospermum) is a rare fungal pathogen that causes disseminated infections. It rarely affects immunocompetent individuals and has a poor prognosis.
Case Presentation: A 37-year-old woman presented with multiple lesions in the lungs, brain, and eyes, shortly after near drowning in a car accident. The primary symptoms were chest tightness, limb weakness, headache, and poor vision in the left eye. S. apiospermum infection was confirmed by metagenomic next-generation sequencing (mNGS) of intracranial abscess drainage fluid, although intracranial metastases were initially considered. After systemic treatment with voriconazole, her symptoms improved significantly; however, she lost vision in her left eye due to delayed diagnosis.
Conclusion: While S. apiospermum infection is rare, it should be considered even in immunocompetent patients. Prompt diagnosis and treatment are essential. Voriconazole may be an effective treatment option.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11017585 | PMC |
| http://dx.doi.org/10.1186/s12883-024-03637-9 | DOI Listing |
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