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Patients with dementia: prevalence and type of drug-drug interactions.
Front Pharmacol
October 2024
Pharmacokinetics, Patient Care and Translational Bioethics Research Group, Catholic University of Murcia (UCAM), Guadalupe, Spain.
Background: Patients with Alzheimer's disease (AD) and other dementias are more frequently exposed to polymedication, mainly due to the presence of comorbidities, are particularly vulnerable to drug-related problems, and present greater risk of adverse effects due to drug-drug interactions (DDIs).
Purpose: To assess the prevalence of clinically relevant interactions in dementia patients using a routine database, we describe the most frequent interactions and risk factors associated with them to facilitate specific interventions and programs to prevent and minimize them.
Methods: An observational, descriptive, and cross-sectional study that included patients with AD and other types of dementia (n = 100, 64% female) was conducted to identify potential DDI in their treatment using the Lexi-Interact/Lexicomp database.
Antihypertensive Medication Category Prescriptions and Blood Pressure Control in African Surinamese and Ghanaian Migrants with Hypertension in Amsterdam, The Netherlands: The HELIUS Study.
High Blood Press Cardiovasc Prev
November 2024
Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
West African (WA) migrants in Europe have higher hypertension rates than the host populations. For African migrants, guidelines recommend diuretics and/or calcium channel blockers (CCB) for primary cardiovascular disease prevention, but data on antihypertensive medication (AHM) prescription patterns or related hypertension control rates are lacking. We assessed AHM prescription patterns and its relation to hypertension control among hypertensive WA migrants in the Netherlands compared to the host population.
View Article and Find Full Text PDFTrends in Drug Duplications in Swedish Older Adults: A Nationwide Register Study from 2006 to 2021.
Drugs Aging
September 2024
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Article Synopsis
- * A study of approximately 1.2 to 1.6 million older adults revealed that potential DD cases grew from 5.2% to 10.6% for ages 65-79 and from 7.0% to 11.7% for those aged 80 and above, with key drugs involved being β-blocking agents and ACE inhibitors in earlier years, evolving to Vitamin B12 and other drugs by 2021.
- * The findings emphasize the need for national strategies to address DD
Management Strategies for Hypertensive Crisis: A Systematic Review.
Cureus
August 2024
Medicine, Najran University, Najran, SAU.
A hypertensive crisis is defined as a sudden and significant rise in blood pressure. The blood pressure reading is 180/120 mmHg or higher. A hypertensive crisis is a medical emergency.
View Article and Find Full Text PDFCarvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease.
PLoS One
August 2024
Department of Clinical Laboratory Technology, Faculty of Medical Science, Juntendo University, Chiba, Japan.
Seizures are increasingly being recognized as the hallmark of Alzheimer's disease (AD). Neuronal hyperactivity can be a consequence of neuronal damage caused by abnormal amyloid β (Aß) depositions. However, it can also be a cell-autonomous phenomenon causing AD by Aß-independent mechanisms.
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