AI Article Synopsis
- Melanocyte stem cells (McSCs) in hair follicles are rare and often overlooked in single-cell RNA sequencing studies.
- Researchers isolated specific cells from the skin of mice to study the detailed characteristics of quiescent McSCs (qMcSCs) and confirmed known subpopulations while also discovering new ones that affect immune response.
- The findings highlight the complexity and diversity within the qMcSC population, suggesting that future research should focus on how changes in these subpopulations impact their functions.
Article Abstract
Melanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, Cdh3+/-) and identified novel qMcSC subpopulations, including two that differentially regulate their immune privilege status. Within qMcSC subpopulations, we also predicted melanocyte differentiation potential, neural crest potential, and quiescence depth. Taken together, the results demonstrate that the qMcSC population is heterogeneous and future studies focused on investigating changes in qMcSCs should consider changes in subpopulation composition.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11178447 | PMC |
| http://dx.doi.org/10.1111/pcmr.13169 | DOI Listing |
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