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Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease. | LitMetric

AI Article Synopsis

  • Exclusive enteral nutrition (EEN) is beneficial for pediatric Crohn disease (CD) remission, but the underlying mechanisms, particularly how pre-diagnosis diet affects microbiome response, are not fully understood.
  • * A study analyzed pre-diagnosis dietary patterns and their relationships with the gut microbiome, disease severity, and EEN treatment outcomes in 98 pediatric patients with CD.
  • * Results showed that a "mature diet" high in fruits, vegetables, and fish was linked to better microbiome diversity and fewer disease flare-ups, while a "pre-packaged" diet of processed foods surprisingly delayed flare-ups in males.*

Article Abstract

Exclusive enteral nutrition (EEN) is effective in inducing remission in pediatric Crohn disease (CD). EEN alters the intestinal microbiome, but precise mechanisms are unknown. We hypothesized that pre-diagnosis diet establishes a baseline gut microbiome, which then mediates response to EEN. We analyzed prospectively recorded food frequency questionnaires (FFQs) for pre-diagnosis dietary patterns. Fecal microbiota were sequenced (16SrRNA) at baseline and through an 18-month follow-up period. Dietary patterns, Mediterranean diet adherence, and stool microbiota were associated with EEN treatment outcomes, disease flare, need for anti-tumor necrosis factor (TNF)-α therapy, and long-term clinical outcomes. Ninety-eight patients were included. Baseline disease severity and microbiota were associated with diet. Four dietary patterns were identified by FFQs; a "mature diet" high in fruits, vegetables, and fish was linked to increased baseline microbial diversity, which was associated with fewer disease flares ( < 0.05) and a trend towards a delayed need for anti-TNF therapy ( = 0.086). Baseline stool microbial taxa were increased ( and ) or decreased ( group) with the mature diet compared to other diets. Surprisingly, a "pre-packaged" dietary pattern (rich in processed foods) was associated with delayed flares in males ( < 0.05). Long-term pre-diagnosis diet was associated with outcomes of EEN therapy in pediatric CD; diet-microbiota and microbiota-outcome associations may mediate this relationship.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11013084PMC
http://dx.doi.org/10.3390/nu16071033DOI Listing

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