AI Article Synopsis
- Some studies indicate that particulate matter (PM) can worsen chronic rhinosinusitis with nasal polyps (CRSwNP) and that retinoic acid (RA) may help in treating this condition.
- PM2.5 exposure leads to increased type 2 inflammation and cytokine production in the nasal mucosa, contributing to the severity of nasal polyps in mice.
- RA supplementation appears to enhance regulatory immune responses by increasing anti-inflammatory cytokine levels, potentially countering the negative effects of PM exposure on CRSwNP.
Article Abstract
Some studies have demonstrated the effects of particulate matter (PM) on chronic rhinosinusitis with nasal polyps (CRSwNP) development, as well as the therapeutic role of retinoic acid (RA) in nasal polypogenesis. However, the immunologic effect of PM in innate lymphoid cells (ILCs) and the exact mechanism of the therapeutic effect of RA remain unclear. Therefore, the present study investigated the effects of fine-dust-induced inflammation in CRSwNP and the mechanisms of the therapeutic effect of RA. PM2.5 exposure exacerbated pathological damage in the nasal mucosa of mice with nasal polyps (NP) via upregulation of type 2 inflammation. Additionally, PM2.5 exposure increased the expression of type 2 cytokines and epithelial-cell-derived cytokines (IL-33 and IL-25) significantly, as well as the ILC populations in human-NP-derived epithelial cells (HNECs). Moreover, RA supplementation significantly increased the expression of ILCreg in Lin-CD45+CD127+ cells, which in turn increased the levels of the anti-inflammatory cytokine IL-10. The findings suggest that PM2.5 exposures could aggravate the CRSwNP type 2 inflammation, and RA treatment may ameliorate fine-dust-induced inflammation by modulating the innate immune response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11011870 | PMC |
| http://dx.doi.org/10.3390/ijms25073856 | DOI Listing |
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