Six new 2-hydroxy ursane triterpenoids, 3---coumaroyloxy-2,19-dihydroxy-12-ursen-28-oic acid (), 3--coumaroyloxy-2,19-dihydroxy-12-ursen-28-oic acid (), 3---coumaroyloxy-2-hydroxy-12-ursen-28-oic acid (), 3--coumaroyloxy-2-hydroxy-12,20(30)-ursadien-28-oic acid (), 3-feruloyloxy-2-hydroxy-12,20(30)-ursadien-28-oic acid (), and 3-feruloyloxy-2-hydroxy-12,20(30)-ursadien-28-oic acid (), along with eleven known triterpenoids (-), were isolated from the leaves of . Their chemical structures were elucidated by comprehensive analysis of UV, IR, HRESIMS, and NMR spectra. All the isolated compounds were evaluated for their PTP1B inhibitory activity. 3---feruloyl-2-hydroxy-urs-12-en-28-oic acid () showed the best inhibition activity with an IC value of 10.32 ± 1.21 μM. The molecular docking study found that the binding affinity of compound for PTP1B was comparable to that of oleanolic acid (positive control).
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| http://dx.doi.org/10.3390/molecules29071640 | DOI Listing |
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