AI Article Synopsis
- - Hepatocellular carcinoma (HCC) is a common liver cancer linked to a high rate of deaths, and several clinical measurements, such as HVPG, TE-LSM, and TAC scores, may help predict patient outcomes.
- - A study involving 144 patients found that higher HVPG, elevated alpha-fetoprotein (AFP) levels, advanced Child-Pugh class, and low TAC scores are independent predictors of overall survival in HCC patients.
- - Analysis revealed significant survival differences based on HVPG values above 10 mmHg and varying TAC score groups, highlighting the importance of these metrics in assessing patient prognosis.
Article Abstract
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child-Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, the main objective of our research was to analyze the prognostic value of the HVPG, TE-LSM, TBS, and TAC scores. An observational and survival study was conducted on 144 subjects. Our findings indicated that HVPG greater than 10 mmHg, AFP surpassing 400 ng/mL, an advanced C-P class, and low TAC score are independent predictors of overall survival. During the multivariate analysis, AFP serum levels and C-P class proved statistically significant. The present study revealed significant differences in overall survival between the two groups divided upon HVPG values and settled by the cutoff of 10 mmHg ( = 0.02). Moreover, by dividing the cohort into three groups based on the TAC score (very low, low, and moderate), statistically significant differences in overall survival were observed across the groups ( = 0.004).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11010842 | PMC |
| http://dx.doi.org/10.3390/cancers16071427 | DOI Listing |
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