AI Article Synopsis
- - Psoriasis is linked to various health issues, including cardiovascular diseases and metabolic syndrome, and there are concerns about its potential connection to certain cancers; however, the safety of biologic treatments in cancer patients with psoriasis is still under scrutiny.
- - A study at the University of Naples evaluated 20 oncology patients with moderate-to-severe psoriasis receiving biologic therapy from 2016 to 2024, where most had a cancer diagnosis prior to treatment, while some developed it during therapy.
- - The commonly used biologics included anti-IL17 and anti-IL23p19 drugs, and all patients in the study experienced improvement in their psoriasis symptoms, suggesting these therapies are effective and safe for psoriasis patients with a cancer history.
Article Abstract
: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evidence on the safety of the use of biologic treatments in cancer patients with psoriasis, and the use of this therapeutic class in patients with a pre-existing or concomitant malignancy is still debated. : We have conducted a retrospective observational study of a group of oncology patients with moderate-to-severe psoriasis treated with biologic therapy at the Dermatology Clinic of the University of Naples Federico II, during the period from 2016 to 2024. We included 20 adult patients; in 15 of them the diagnosis of neoplasm preceded the start of treatment biologic, while four of these patients had been diagnosed with cancer during the course of therapy biologics. : The most represented neoplasms in our population were breast carcinoma, prostate carcinoma, thyroid carcinoma, and chronic lymphatic leukemia. Anti-IL17 drugs were the most frequently prescribed (47.7%), followed by anti-IL23p19 (36.8%), anti-IL-12/23 (10.5%) and anti-TNF alpha (5.26%). All patients showed improvement of psoriasis after starting the therapy. : Our experience supports the effectiveness and safety of biological therapy for psoriasis in patients with a history of cancer or recent onset neoplasia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11012886 | PMC |
| http://dx.doi.org/10.3390/jcm13071940 | DOI Listing |
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