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Butyl Imidates: Highly Stable and Isolable Synthetic Intermediates.
J Org Chem
January 2025
U.S. Process Chemistry, CMC Synthetics Platform, Sanofi, 350 Water Street, Cambridge, Massachusetts 02141, United States.
Imidates are versatile synthetic intermediates that contain ambiphilic reactivity, making them valuable pharmaceutically relevant synthons. Despite their extensive utility, imidates are typically generated in situ rather than isolated due to their inherent instability. This report details a systematic study that led to the discovery of an isolable imidate hydrogen chloride (HCl) salt that exhibits high tolerance to hydrolysis, thereby improving process control and facilitating downstream transformations.
View Article and Find Full Text PDFFecal carriage of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in South American camelids and biosecurity practices among farms in northern Italy.
Vet Res Commun
January 2025
Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, 26900, Italy.
South American camelids (SACs), particularly llamas (Lama glama) and alpacas (Vicugna pacos) are gaining popularity in Europe. Initially valued for their fiber and land management capabilities, these animals are now also kept for animal therapy, outdoor activities, and as companion animals. Despite their close interactions with humans and other animals, there is limited research on the transmission of microbes or antimicrobial resistance genes from SACs.
View Article and Find Full Text PDFThe Impact of Rest Intervals on the Force-Velocity Relationship Obtained During the Keiser's 10-Repetition Leg Press Test.
J Funct Morphol Kinesiol
January 2025
School of Health Sciences, Kristiania University College, 0153 Oslo, Norway.
The Keiser 10-rep leg press test protocol employs short inter-repetition rest intervals (2-38 s), raising concerns as to whether athletes perform optimally. The aim of this study was to compare the results of the standard Keiser protocol with an identical protocol modified to include a significantly longer inter-repetition rest intervals and to evaluate whether these effects differed between men and women. A total of 30 athletes (age 17.
View Article and Find Full Text PDFLocalized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions.
Int J Nanomedicine
January 2025
Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt.
Different types of cancers affect the gastrointestinal tract (GIT), starting from the oral cavity and extending to the colon. In general, most of the current research focuses on the systemic delivery of the therapeutic agents, which leads to undesired side effects and a limited enhancement in the therapeutic outcomes. As a result, localized delivery within gastrointestinal (GI) cancers is favorable in overcoming these limitations.
View Article and Find Full Text PDFWearable optical coherence tomography angiography probe with extended depth of field.
J Biomed Opt
January 2025
Tsinghua University, State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Beijing, China.
Significance: Optical coherence tomography (OCT) is widely utilized to investigate brain activities and disorders in anesthetized or restrained rodents. However, anesthesia can alter several physiological parameters, leading to findings that might not fully represent the true physiological state. To advance the understanding of brain function in awake and freely moving animals, the development of wearable OCT probes is crucial.
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