AI Article Synopsis
- The SERPINA1 gene produces Alpha-1 Antitrypsin (AAT1), which plays a role in balancing proteases and antiproteases; imbalances may contribute to severe health issues, including those related to COVID-19.
- This study aimed to analyze the relationship between AAT1 levels and the severity of COVID-19 symptoms in 181 hospitalized patients.
- Results showed that higher AAT1 levels correlated with increased severity, longer hospitalization, inflammatory markers, and worse outcomes, suggesting AAT1 could serve as a useful prognostic biomarker in COVID-19 cases.
Article Abstract
Introduction: The SERPINA1 gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to the development of serious pulmonary and extrapulmonary pathologies. In this work we study the importance of this possible imbalance in patients with COVID-19.
Objectives: To correlate the severity of the symptoms of SARS-COV-2 infection with the AAT1 concentrations at diagnosis of the disease.
Methods: An observational, prospective, cross-sectional, non-interventional, analytical study was carried out where 181 cases with COVID-19 admitted to the "Lozano Blesa" University Clinical Hospital of Zaragoza were selected. The concentration of AAT1 was studied in all of them and this was correlated with the clinical aspects and biochemical parameters at hospital admission.
Results: 141 cases corresponded to patients with severe COVID and 40 patients with mild COVID. AAT1 levels were positively correlated with the days of hospitalization, severity, C-Reactive Protein, ferritin, admission to Intensive Care, and death, and presented a negative correlation with the number of lymphocytes/mm3. AAT1 concentrations higher than 237.5 mg/dL allowed the patient to be classified as "severe" (S72%; E78%) and 311.5 mg/dL were associated with the risk of admission to Intensive Care or Exitus (S67%; E79%).
Conclusions: Levels of the SERPINA1 gene expression product, AAT1, correlate with the severity of COVID-19 patients at diagnosis of the disease, being useful as a prognostic biomarker.
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| http://dx.doi.org/10.1016/j.rceng.2024.04.006 | DOI Listing |
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Article Synopsis
- Alpha-1 Antitrypsin Deficiency (AATD) is linked to higher risks of lung and liver diseases, primarily associated with the common PI*ZZ genotype.
- Researchers studied patients with severe AATD from the Italian Registry for AATD, focusing on those with rare genotypes like PI*R.
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