Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C-H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.4c00604 | DOI Listing |
Publication Analysis
Top Keywords
isoquinolone scaffolds
8
scaffolds dna
8
dna rhodiumiii-catalyzed
8
rhodiumiii-catalyzed c-h
8
c-h activation
8
construction isoquinolone
4
activation isoquinolone
4
isoquinolone common
4
common heterocyclic
4
heterocyclic core
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!