Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction.

Aging Dis

Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.

Published: October 2024

AI Article Synopsis

  • * Recent advances in genomics and precision medicine enable a better understanding of dementia's genetic basis, which can lead to tailored treatment strategies.
  • * By exploring gene-environment interactions, precision medicine aims to identify at-risk individuals and develop targeted therapies, potentially improving prevention and management of dementia.

Article Abstract

The diagnosis, treatment, and management of dementia provide significant challenges due to its chronic cognitive impairment. The complexity of this condition is further highlighted by the impact of gene-environment interactions. A recent strategy combines advanced genomics and precision medicine methods to explore the complex genetic foundations of dementia. Utilizing the most recent research in the field of neurogenetics, the importance of precise genetic data in explaining the variation seen in dementia patients can be investigated. Gene-environment interactions are important because they influence genetic susceptibilities and aid in the development and progression of dementia. Modified to each patient's genetic profile, precision medicine has the potential to detect groups at risk and make previously unheard-of predictions about the course of diseases. Precision medicine techniques have the potential to completely transform treatment and diagnosis methods. Targeted medications that target genetic abnormalities will probably appear, providing the possibility for more efficient and customized medical interventions. Investigating the relationship between genes and the environment may lead to preventive measures that would enable people to change their surroundings and minimize the risk of dementia, leading to the improved lifestyle of affected people. This paper provides a comprehensive overview of the genomic insights into dementia, emphasizing the pivotal role of precision medicine, and gene-environment interactions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346410PMC
http://dx.doi.org/10.14336/AD.2024.0322DOI Listing

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