AI Article Synopsis
- The study aimed to explore the link between genetic variations in cytokine genes and the occurrence of peri-implantitis, a dental health issue that shows varying results across different populations.
- A total of 102 Caucasian Portuguese participants were analyzed, with findings indicating that while the IL-1A-889 C/T polymorphism was more prevalent in peri-implantitis patients, it was not statistically significant.
- Overall, the investigated genetic polymorphisms did not affect the occurrence of peri-implantitis in this group, highlighting the need for more research across diverse populations to understand the genetic factors involved in peri-implant diseases.
Article Abstract
Purpose: To investigate whether genetic variations in cytokine genes involved in the pathogenesis of peri-implantitis are associated with the occurrence of peri-implantitis, an issue that remains controversial and may vary according to the population evaluated.
Materials And Methods: A cross-sectional analytical study was carried out on 102 Caucasian Portuguese individuals who were divided into two groups: (1) 43 individuals with peri-implantitis and (2) 59 individuals with good peri-implant health. Samples from the buccal mucosa were obtained, and genetic analysis was performed using the real-time polymerase chain reaction (PCR) technique for IL-1A and IL-1B and PCR for IL-1RN.
Results: The IL-1A-889 C/T polymorphism presented with a higher prevalence of the less common allele (T allele) in patients with peri-implantitis (27.9%) than in healthy patients (16.9%), but without statistical significance (P = .060). For the IL-1B+3954 C/T and IL-1RN (variable number of tandem repeats [VNTR]) polymorphisms, analysis revealed that the allele and genotype frequencies did not differ significantly between groups. There was a significant association between a history of periodontitis and peri-implantitis (P = .020).
Conclusions: The evaluated genetic polymorphisms had no influence on the occurrence of peri-implantitis in the study population. Further research into genetic variations in different populations is needed to elucidate the role of genetic factors in the onset and progression of peri-implant disease.
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| http://dx.doi.org/10.11607/jomi.10615 | DOI Listing |
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