AI Article Synopsis
- Patients with Lynch syndrome have a higher risk of developing colorectal cancer and other cancers at a younger age, requiring specialized management.
- The management of rectal cancer in these patients involves complex decisions such as whether to perform proctectomy alone or total proctocolectomy, and the use of chemotherapy, immunotherapy, and nonoperative options.
- The review emphasizes balancing cancer risk reduction with improving patients' quality of life in treatment decisions.
Article Abstract
Patients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision between proctectomy alone versus total proctocolectomy with or without an ileal pouch, the utility of chemotherapy and immunotherapy, nonoperative rectal cancer management, and the management of rectal polyps. Throughout, we highlight the delicate interplay between future cancer risk reduction and quality of life optimization.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006439 | PMC |
| http://dx.doi.org/10.1055/s-0043-1770730 | DOI Listing |
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