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Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children.
J Clin Endocrinol Metab
January 2025
Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8575, Japan.
Background: The association of maternal hyperglycemia with childhood developmental delay has been examined; however, only 2 studies used maternal blood glucose level as a continuous variable as an exposure. A present study aimed to investigate the influence of maternal fasting plasma glucose (mFPG) level in early gestation on developmental delay in children.
Methods: This cohort study included 1541 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Hunting for heroes: Brain neurons mediating GLP-1R agonists in obesity treatment.
Obes Med
December 2024
The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, MD Anderson Cancer Center & UTHealth Houston Graduate School for Biomedical Sciences, University of Texas Health Science at Houston, Texas, 77030, USA.
Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RAs) have proven to be highly effective in reducing obesity across species and ages, gaining unmet popularity in clinical treatments against obesity. Although extensive research efforts have been made to explore how the brain regulates body weight homeostasis including the effect brought up by GLP-1 and its synthetic analogs GLP-1RAs, the identity of neurons and neural pathways that are responsible for the observed anti-obesity effect of GLP-1RAs remain largely elusive. Excitingly, three recent high-profile studies presented compelling evidence that each argues for the importance of GLP-1Rs in the dorsomedial hypothalamus, hindbrain, or lateral septum, respectively, in mediating the anti-obesity effect of GLP-1RAs.
View Article and Find Full Text PDFVitiligo Exchange: An Expert Panel Discussion of Two Clinical Cases.
J Clin Aesthet Dermatol
December 2024
Dr. Grimes is the Founder and Director at the Vitiligo & Pigmentation Institute of Southern California in Los Angeles, California; Clinical Professor of Dermatology at the University of California, Los Angeles. Current President of the Global Vitiligo Foundation.
This article is based on a roundtable discussion in which three panelists review clinically relevant insights about vitiligo and discuss two cases that illustrate the multiple challenges faced by both patients and clinicians in managing this complex disease. The first is a 32-year-old White female patient with Fitzpatrick Skin Type III/IV with extensive depigmentation in the trunk area. The patient achieved 90-percent repigmentation with a combination therapy approach.
View Article and Find Full Text PDFObjective: The digitalization of our daily living has changed dramatically the internet and digital media use among all ages. However, children and adolescents are particularly vulnerable to potential dangers and addiction risks. Our objective was to evaluate the computer and internet addiction levels in children and adolescents through their parents' reports.
View Article and Find Full Text PDFPandemic mothering: Mothers' experiences of adaptation and resilience during the COVID-19 pandemic.
Child Fam Soc Work
November 2024
School of Social Work, University of Texas-Arlington School of Social Work, Arlington, Texas, 76019-0129, USA.
Research suggests that the demands of have increased during the COVID-19 pandemic, especially for mothers. Widespread loss of childcare and in-person schooling forced parents to make adjustments to care for their children in new ways, many while working remotely. This qualitative study, guided by Walsh's theory of family resilience, examines mothers' experiences with stress and resilience as they adapted to the COVID-19 pandemic.
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