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Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study. | LitMetric

Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study.

Diabetes Res Clin Pract

Patient Safety Faculty Group, Health Service Management Training Centre, Semmelweis University, 2, Kútvölgyi Str., Budapest H-1125, Hungary; NEVES Society, 60, Tárogató Str., Budapest H-1021, Hungary; Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre, Semmelweis University, 2, Kútvölgyi Str., Budapest H-1125, Hungary. Electronic address:

Published: May 2024

AI Article Synopsis

Article Abstract

Aims: To investigate the risk of cancer in people with diabetes compared to the population without diabetes and to gain insight into the timely association between diabetes and cancer at national level.

Methods: A retrospective cohort study was conducted to analyse the role of diabetes in the development of cancer, based on service utilisation and antidiabetic dispensing data of the population between 2010 and 2021. Univariate and multivariate Cox regression were used to examine how diabetes status, in relationship with age and sex are related to the time to cancer diagnosis.

Results: Examining a population of 3 681 774 individuals, people with diabetes have a consistently higher risk for cancer diagnosis for each cancer site studied. Diabetes adds the highest risk for pancreatic cancer (HR = 2.294, 99 % CI: 2.099; 2.507) and for liver cancer (HR = 1.830, 99 % CI: 1.631; 2.054); it adds the lowest - but still significant - risk for breast cancer (HR = 1.137, 99 % CI: 1.055; 1.227) and prostate cancer (HR = 1.171, 99 % CI: 1.071; 1.280).The difference in cancer rate is driven by the younger age group (40-54 years: for patients with diabetes 5.4 % vs. controls 4.4 %; 70-89 years: for patients with diabetes 12.7 % vs. controls 12.4 %). There are no consistent results whether the presence of diabetes increases the risk of cancer diagnosis differently in males and females. The cancer incidence starts to increase before the diagnosis of diabetes and peaks in the year after. By the year after the start of the inclusion date, the incidence is 114/10,000 population in the control group, vs 195/10,000 population in the group with diabetes. Following this, the incidence drops close to the control group.

Conclusions: Screening activities should be revised and the guidelines on diabetes should be complemented with recommendations on cancer prevention also considering that the cancer incidence is highest around the time of the diagnosis of diabetes. For prostate cancer, our results contradict many previous studies, and further research is recommended to clarify this.

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Source
http://dx.doi.org/10.1016/j.diabres.2024.111665DOI Listing

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