In the 1990s, neonates born with severe congenital heart disease faced more than 50% mortality awaiting an ABO-compatible (ABOc) transplant donor. This desperate situation, together with knowledge of gaps in the adaptive immune system in early childhood, led to the clinical exploration of intentional ABO-incompatible (ABOi) heart transplantation. In 2001, West et al. reported the first series of 10 infants in Canada. Since then, consideration of ABOi heart donors has become the standard of care for children awaiting transplantation in the first few years of life, resulting in reduced wait times and better organ utilization with noninferior post-transplant outcomes compared to ABOc recipients. This state-of-the-art review discusses the clinical development and evolution, underlying and resulting immunological aspects, current challenges, and future directions of ABOi heart transplantation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.healun.2024.03.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single center experience with ABO-incompatible and ABO-compatible pediatric heart transplantation.
Front Transplant
October 2024
Department of Heart Surgery, Ludwig Maximilian University Munich, Munich, Germany.
Introduction: The aim of this study was to analyze the results after pediatric heart transplantation (pHTx) at our single center differentiating between ABO-incompatible (ABOi) and -compatible (ABOc) procedures.
Methods And Patients: We retrospectively analyzed outcomes of ABO-incompatible HTx procedures performed at our center and compared the data to ABO-compatible HTx of the same era. Eighteen children (<17 months) underwent pediatric HTx and seven of them underwent ABO-incompatible HTx between 2003 and 2015.
Long-term isoagglutinin monitoring after ABO-incompatible kidney transplantation.
Am J Clin Pathol
September 2024
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Article Synopsis
- * Researchers reviewed patients who experienced elevated ABO antibody levels and suspected acute antibody-mediated rejection (AMR) after their transplants at Asan Medical Center, gathering clinical and laboratory data over a two-year period.
- * The results showed that three patients developed acute AMR within two weeks, suggesting that this monitoring period might be too short, and the study advocates for longer monitoring and additional treatments to enhance kidney transplant survival.
Inclusive ABO-Incompatible Listing for Pediatric Heart Transplantation Results in Comparable Post-Transplant Rejection-Free Survival in a Single-Center Series.
Pediatr Cardiol
August 2024
Children's Hospital of Colorado, 13123 East 16th Ave., B200, Aurora, CO, 80045, USA.
ABO-incompatible (ABOi) heart transplantation (HT) has increased organ availability for infants with end-stage heart failure. Despite increasing adoption of ABOi listing for HT, data remain limited regarding pre- and post-HT immunologic profiles to guide listing practices and post-HT follow-up. Thus, the purpose of this study was to evaluate post-HT outcomes at a single center employing inclusive ABOi listing irrespective of pre-HT isohemagglutinin titers.
View Article and Find Full Text PDFDual immunoadsorption for ABO-incompatible heart transplantation in a 35 kg child.
Perfusion
August 2024
Department of Perfusion, Great Ormond Street Hospital for Children, London, UK.
Intraoperative anti-A/B immunoadsorption (ABO-IA) was recently introduced for ABO-incompatible (ABOi) heart transplantation. Here we report the first case of a patient transplanted with ABO-IA, that was of an age and weight that required two ABO-IA columns run in parallel, to enable the reduction in antibody titres to a sufficiently low level in the time available during implantation of the donor organ.
View Article and Find Full Text PDFABO-incompatible heart transplantation-evolution of a revolution.
J Heart Lung Transplant
September 2024
Department of Pediatrics, University of Alberta/Stollery Children's Hospital, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada.
In the 1990s, neonates born with severe congenital heart disease faced more than 50% mortality awaiting an ABO-compatible (ABOc) transplant donor. This desperate situation, together with knowledge of gaps in the adaptive immune system in early childhood, led to the clinical exploration of intentional ABO-incompatible (ABOi) heart transplantation. In 2001, West et al.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!