Cancer patients and ischemic stroke.

Thromb Res

UNC Blood Research Center, Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Published: May 2024

AI Article Synopsis

  • Patients with cancer have a higher risk of ischemic stroke and a worse prognosis than those without cancer.
  • The activation of coagulation is thought to significantly contribute to the occurrence of ischemic strokes in cancer patients, but the exact mechanisms are not yet understood.
  • There is an urgent need for healthcare professionals, particularly neurologists and oncologists, to create screening and prevention strategies for stroke in cancer patients.

Article Abstract

Patients with cancer have an increased risk of ischemic stroke compared to the general population. Additionally, these patients have a worse prognosis compared to stroke patients without cancer. Activation of coagulation appears to play a key role in the pathophysiology of ischemic stroke in patients with cancer. However, the underlying mechanisms remain unknown. Moreover, we do not have a way to identify cancer patients with a high risk of stroke and cannot develop prevention strategies. Therefore, there is an urgent need for neurologists and oncologists to develop screening and prevention strategies for stroke in patients with cancer. In this review, we summarize the characteristics of cancer patients at a high risk of stroke, the predictors for the development of stroke and survival in cancer patients, and possible treatments.

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Source
http://dx.doi.org/10.1016/j.thromres.2024.03.019DOI Listing

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