AI Article Synopsis
- There is substantial research on perineural invasion (PNI) in cutaneous squamous cell carcinoma (cSCC), but less is known about lymphovascular invasion (LVI) and how to manage it.
- This article aims to review existing studies on LVI in cSCC and provide evidence-based management recommendations.
- Findings indicate that LVI significantly increases the risk of poor outcomes, suggesting that tumors with LVI should be treated similarly to those with PNI due to their high-risk status.
Article Abstract
Background: Although there is a large body of literature regarding risk stratification and outcomes for perineural invasion (PNI) in cutaneous squamous cell carcinoma (cSCC), there is a relative paucity of studies exploring the role of lymphovascular invasion (LVI) in cSCC and a lack of clear evidence-based guidelines for how to manage patients with these tumors.
Objective: This article is intended to review the available literature regarding LVI in cSCC and formulate evidence-based recommendations for clinical management.
Methods And Materials: A literature review was conducted using PubMed to find relevant articles relating to outcomes and management of primary cSCC with LVI.
Results: The available literature suggests that LVI is a major risk factor for poor outcomes and increased morbidity and mortality in cSCC.
Conclusion: Lymphovascular invasion is a very high-risk feature that should place these tumors in the highest-risk category, and management of these tumors should be similar to that of squamous cell carcinoma with PNI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/DSS.0000000000004187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sentinel lymph node biopsy for early stage vulvar squamous cell carcinoma.
Proc (Bayl Univ Med Cent)
September 2024
Department of Surgery, Baylor University Medical Center, Dallas, Texas, USA.
Background: Patients with regional lymph node involvement from squamous cell carcinoma (SCC) of the vulva have a 48% 5-year relative survival. Recently, sentinel lymph node (SLN) biopsy has become a viable alternative to inguinofemoral lymphadenectomy. We sought to identify risk factors for predicting a positive SLN in patients with vulvar SCC.
View Article and Find Full Text PDFNomogram for predicting post-progression-free survival in patients with recurrent pancreatic ductal adenocarcinoma after radical surgery: a retrospective analysis.
Front Med (Lausanne)
December 2024
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Background: Radical resection is the only curative method for patients with pancreatic adenocarcinoma (PDAC). However, nearly 85% of PDAC patients suffer from local or distant recurrence within 5 years after curative resection. The progression of recurrent lesions accelerates the mortality rate in PDAC patients.
View Article and Find Full Text PDFPathological features of the differentiation landscape in esophageal squamous cell cancer and their correlations with prognosis.
Front Oncol
December 2024
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: For esophageal squamous cell carcinoma (ESCC), universally accepted pathological criteria for classification by differentiation degree are lacking. Tumor budding, single-cell invasion, and nuclear grade, recognized as prognostic factors in other carcinomas, have rarely been investigated for their correlation with differentiation and prognosis in ESCC. This study aims to determine if pathological findings can predict differentiation degree and prognosis in ESCC.
View Article and Find Full Text PDFPredictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group.
Ann Surg Open
December 2024
From the Chirurgia Generale ed Epatobiliare, Azienda Ospedaliera Universitaria Integrata di Verona, Università degli Studi di Verona, Verona, Italy.
Objective: The aim of this study is to provide solid evidence to update the management of stage I colon cancer (CC) after surgery.
Background: Given the low risk of recurrence of stage I CC, some international guidelines do not recommend intensive follow-up after surgery. However, data on the actual incidence, risk factors, and site of recurrences are scarce.
Applicability of the Scottish screen-detected polyp cancer study (SSPoCS) algorithm in a multicentric cohort in the management of malignant colorectal polyps.
Scand J Gastroenterol
December 2024
Gastroenterology Department, Centro Hospitalar de Leiria, Leiria, Portugal.
Background/objectives: Robust evidence regarding the management after endoscopic resection of malignant colorectal polyps (MCP) is lacking. Inconsistencies in reporting on potential prognostic factors hinder the decision process. To address these issues, the Scottish Screen-detected Polyp Cancer Study (SSPoCS) introduced an algorithm based in two easily obtainable variables: resection margin and lymphovascular invasion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!