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The Effects of Moderate to High Static Magnetic Fields on Pancreatic Damage.
J Magn Reson Imaging
January 2025
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Background: Pancreatic damage is a common digestive system disease with no specific drugs. Static magnetic field (SMF), the key component of magnetic resonance imaging (MRI), has demonstrated prominent effects in various disease models.
Purpose: To study the effects of 0.
Comparing the cost of cirrhosis to other common chronic diseases: A longitudinal study in a large national insurance database.
Hepatology
January 2025
Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Background Aims: Cirrhosis prevalence is increasing, yet costs associated with its chronic, complex care are poorly understood. The aim was to characterize the costs of care for patients with cirrhosis and compare them to other chronic diseases such as heart failure (HF) and chronic obstructive pulmonary disease (COPD), for which the public health burden is better recognized.
Approach: Patients enrolled in Medicare Advantage plans from a large national insurer between 2011-2020 with cirrhosis, HF, and COPD were identified by ICD-9/-10 codes.
Post-translational modifications drive the effects of HMGB1 in alcohol-associated liver disease.
Hepatol Commun
November 2024
Department of Pathology, University of Illinois Chicago, Chicago, Illinois, USA.
Article Synopsis
- High-mobility group box-1 (HMGB1) levels rise and undergo post-translational modifications (PTMs) with alcohol consumption, potentially influencing the development of alcohol-associated liver disease (AALD).
- Researchers used a specific model of liver injury caused by alcohol to explore how manipulating HMGB1's expression and modifications in liver cells and immune cells impacts AALD.
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Impact of chronic ethanol consumption and SARS-COV-2 on the liver and intestine: A pilot dose-response study in mice.
Alcohol Clin Exp Res (Hoboken)
January 2025
Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA.
Background: During the coronavirus disease 2019 (COVID-19) pandemic, there was a marked increase in alcohol consumption. COVID-19 superimposed on underlying liver disease notably worsens the outcome of many forms of liver injury. The goal of a current pilot study was to test the dual exposure of alcohol and COVID-19 infection in an experimental animal model of alcohol-associated liver disease (ALD).
View Article and Find Full Text PDFSirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C Motif) Ligand 2 Secretion through the NF-κB Signaling Pathway.
Am J Pathol
December 2024
The Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, The Key Laboratory of Model Animals and Stem Cell Biology of Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Pharmaceutical Science, Changsha, China. Electronic address:
Article Synopsis
- The progression of Alcohol-associated liver disease (ALD) involves increased gut permeability due to ethanol, leading to bacterial products entering the bloodstream and causing liver inflammation and damage.
- The study used mice without the SIRT7 gene in myeloid cells, finding that this knockout reduced liver injury and inflammation caused by alcohol while minimally impacting lipid metabolism.
- Identification of CCL2 as a key target affected by SIRT7 highlights how its knockout hinders macrophage CCL2 secretion and monocyte recruitment, suggesting that targeting SIRT7 could provide new treatment strategies for ALD.
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