The global COVID-19 crisis has severely affected mass transit in the cities of the global south. Fear of widespread propagation in public spaces and the dramatic decrease in human mobility due to lockdowns have resulted in a significant reduction of public transport options. We analyze the case of TransMilenio in Bogotá, a massive Bus Rapid Transit system that is the main mode of transport for an urban area of roughly 10 million inhabitants. Concerns over social distancing and new health regulations reduced the number of trips to under 20% of its historical values during extended periods of time during the lockdowns. This has sparked a renewed interest in developing innovative data-driven responses to COVID-19 resulting in large corpora of TransMilenio data being made available to the public. In this paper we use a database updated daily with individual passenger card swipe validation microdata including entry time, entry station, and a hash of the card's ID. The opportunity of having daily detailed minute-to-minute ridership information and the challenge of extracting useful insights from the massive amount of raw data (∼1,000,000 daily records) require the development of tailored data analysis approaches. Our objective is to use the natural representation of urban mobility offered by networks to make pairwise quantitative similarity measurements between daily commuting patterns and then use clustering techniques to reveal behavioral disruptions as well as the most affected geographical areas due to the different pandemic stages. This method proved to be efficient for the analysis of large amount of data and may be used in the future to make temporal analysis of similarly large datasets in urban contexts.
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http://dx.doi.org/10.1177/23998083221150646 | DOI Listing |
Blood Adv
January 2025
Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy.
Although recent evidence suggests that myeloid clonal hematopoiesis (M-CH) may influence lymphoma clinical outcome, its impact in mantle cell lymphoma (MCL) remains unclear. Here, we report a comprehensive NGS-based analysis of the M-CH mutational landscape at baseline and follow-up in patients enrolled in the Fondazione Italiana Linfomi (FIL) MCL0208 phase 3 trial (NCT02354313), evaluating lenalidomide maintenance versus observation after chemoimmunotherapy and autologous stem cell transplantation (ASCT) in untreated young MCL patients. Overall, 254/300 (85%) enrolled patients (median age 57 years [32-66]) had a baseline sample available for CH analysis.
View Article and Find Full Text PDFJ Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Tokyo (Dr. Kono, Dr. Taketomi, Dr. Kage, Dr. Inui, and Dr. Tanaka); the Department of Information Systems, Faculty of Engineering, Saitama Institute of Technology, Fukaya, Saitama (Dr. Yamazaki); the Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Suita, Osaka (Dr. Tamaki, and Dr. Tomita); the Department of Orthopedic Surgery, Saitama Medical University, Saitama Medical Center, Kawagoe, Saitama (Dr. Inui); and the Department of Health Science, Graduate School of Health Science, Morinomiya University of Medical Sciences, Suminoe, Osaka, Japan (Dr. Tomita).
Background: The effect of axial rotation between the femoral neck and ankle joint (total rotation [TR]) on normal knees is unknown. Therefore, this study aimed to investigate the TR effect on normal knee kinematics.
Methods: Volunteers were divided into groups large (L), intermediate (I), and small (S), using hierarchical cluster analysis based on TR in the standing position.
J Nat Prod
January 2025
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
(-)-Cryptanoside A () was identified previously as a major cytotoxic component of the stems of collected in Laos, which mediates its activity by targeting Na/K-ATPase (NKA), with hydrogen bonds formed between its 11- and 4'-hydroxy groups and NKA being observed in its docking profile. In a continuing investigation, and its 17-epimer, (-)-17--cryptanoside A (), and the new (+)-2-hydroxyandrosta-4,6-diene-3-one-17-carboxylic acid () and the known (+)-2,21-dihydroxypregna-4,6-diene-3,20-dione or 2-hydroxy-6,7-didehydrocortexone () pregnane-type steroids were isolated from . In addition, (-)-11,4'-di--acetylcryptanoside A () has been synthesized from the acetylation of .
View Article and Find Full Text PDFJ Clin Gastroenterol
January 2025
Department of Gastroenterology and Hepatology Creighton University, Omaha, NE.
Introduction: Thermal ablative methods (such as argon plasma coagulation (APC) and soft tip snare coagulation (STSC) are commonly used to treat polyp margins. We aim to appraise the current literature and compare clinical outcomes between patients with treated (with APC vs. STSC) and non-treated endoscopic mucosal resection (EMR) margins.
View Article and Find Full Text PDFPLoS One
January 2025
Orthopedics Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Objective: The objective of this systematic review and meta-analysis is to clarify the rehabilitation efficacy of virtual reality (VR) balance training after anterior cruciate ligament reconstruction (ACLR).
Methods: This meta-analysis was registered in PROSPERO with the registration number CRD42024520383. The electronic databases PubMed, Web of Science, Cochrane Library, MEDLINE, Embase, China National Knowledge Infrastructure, Chinese Biomedical Literature, China Science and Technology Journal Database, and Wanfang Digital Periodical database were systematically searched to identify eligible studies from their inception up to January 2024.
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