Adamantylglycine as a high-affinity peptide label for membrane transport monitoring and regulation.

Chem Commun (Camb)

Center for Cellular Nanoanalytics (CellNanOs) and Department of Biology and Chemistry, Universität Osnabrück, Barbarastraße 7, Osnabrück 49069, Germany.

Published: April 2024

The non-canonical amino acid adamantylglycine (Ada) is introduced into peptides to allow high-affinity binding to cucurbit[7]uril (CB7). Introduction of Ada into a cell-penetrating peptide (CPP) sequence had minimal influence on the membrane transport, yet enabled up- and down-regulation of the membrane transport activity.

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Source
http://dx.doi.org/10.1039/d4cc00602jDOI Listing

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