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Peripheral Blood Cells From Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function. | LitMetric

AI Article Synopsis

  • Blood-based mitochondrial bioenergetic profiling is a practical and low-risk method for studying mitochondrial function and energy metabolism using human blood samples.
  • The study employs two respirometric techniques to assess mitochondrial bioenergetics in peripheral blood mononuclear cells and platelets, revealing that female participants exhibit significantly higher respiration rates than male participants, even after adjusting for other variables.
  • Findings highlight the importance of considering sex differences in mitochondrial bioenergetic profiles, particularly in the context of human health and aging research.

Article Abstract

Blood-based mitochondrial bioenergetic profiling is a feasible, economical, and minimally invasive approach that can be used to examine mitochondrial function and energy metabolism in human subjects. In this study, we use 2 complementary respirometric techniques to evaluate mitochondrial bioenergetics in both intact and permeabilized peripheral blood mononuclear cells (PBMCs) and platelets to examine sex dimorphism in mitochondrial function among older adults. Employing equal numbers of PBMCs and platelets to assess mitochondrial bioenergetics, we observe significantly higher respiration rates in female compared to male participants. Mitochondrial bioenergetic differences remain significant after controlling for independent parameters including demographic parameters (age, years of education), and cognitive parameters (mPACC5, COGDX). Our study illustrates that circulating blood cells, immune cells in particular, have distinctly different mitochondrial bioenergetic profiles between females and males. These differences should be taken into account as blood-based bioenergetic profiling is now commonly used to understand the role of mitochondrial bioenergetics in human health and aging.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059251PMC
http://dx.doi.org/10.1093/gerona/glae098DOI Listing

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