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A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis. | LitMetric
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A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis.

Kaiye Wang Xiaohan Liu Yuting Jia Limeng Pan Mingwan Shi Wei Pan Na Li Bo Tang

Chem Commun (Camb)

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

Published: April 2024

A small-molecule Fenton reagent, integrating ferrocene with a carbonic anhydrase inhibitor, was designed to intelligently regulate intracellular acidosis for self-augmented chemodynamic therapy. Acidosis coupled with up-regulated ROS levels demonstrated potent cytotoxicity and effective tumor suppression.

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 Source
http://dx.doi.org/10.1039/d4cc00760cDOI Listing

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