Multidrug resistance is the main obstacle to cancer chemotherapy. Overexpression of drug efflux pumps causes excessive drug efflux from cancer cells, ultimately leading to drug resistance. Hereby, we raise an effective strategy to overcome multidrug resistance using a synergistic combination of membranolytic antitumor β-peptide polymer and chemotherapy drugs. This membrane-active β-peptide polymer promotes the transmembrane transport of chemotherapeutic drugs by increasing membrane permeability and enhances the activity of chemotherapy drugs against multidrug-resistant cancer cells. As a proof-of-concept demonstration, the synergistic combination of β-peptide polymer and doxorubicin (DOX) is substantially more effective than DOX alone against drug-resistant cancer both and . Notably, the synergistic combination maintains a potent anticancer activity after continuous use. Collectively, this combination therapy using membrane lytic β-peptide polymer appears to be an effective strategy to reverse anticancer drug resistance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.4c00434 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Structurally Simple Polymer Donor Enables High-Efficiency Organic Solar Cells with Minimal Energy Losses.
Angew Chem Int Ed Engl
March 2025
South China University of Technology, State Key Laboratory of Luminescent Materials and Devices, Wushan Road 381, 510640, Guangzhou, CHINA.
Energy loss (Eloss) between optical energy gap (Eg) and open-circuit voltage (eVoc) sets efficiency upper limits for organic solar cells (OSCs). Nevertheless, further breaking the limit of Eloss in OSCs is challenging, especially via structurally simple materials in binary OSCs. Herein, a structurally simple non-halogenated polymer donor, namely PBDCT, is developed for realizing high-efficiency OSCs with record-breaking Eloss.
View Article and Find Full Text PDFIn Situ Raman Spectra and Machine Learning Assistant Thermal Annealing Optimization for Effective Phototransistors.
ACS Appl Mater Interfaces
March 2025
State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, P. R. China.
The relationship between the structure and function of condensed matter is complex and changeable, which is especially suitable for combination with machine learning to quickly obtain optimized experimental conditions. However, little research has been done on the effect of temperature on condensed matter and how it affects device performance because the difference between the in situ physical property parameters (which are lowered by the surface tension and mixing entropy) and the basic parameters of the bulk makes accurate AI predictions difficult. In this work, P3HT/ITIC was chosen as the donor/acceptor material for the active layer of organic phototransistors (OPTs).
View Article and Find Full Text PDFDeep-Learning-Assisted Understanding of the Self-Assembly of Miktoarm Star Block Copolymers.
ACS Nano
March 2025
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
The self-assemblies of topological complex block copolymers, especially the AB type miktoarm star ones, are fascinating topics in the soft matter field, which represent typical self-assembly behaviors analogous to those of biological membranes. However, their diverse topological asymmetries and versatile spontaneous curvatures result in rather complex phase separations that deviate significantly from the common mechanisms. Thus, numerous trial-and-error experiments with tremendous parameter space and intricate relationships are needed to study their assemblies.
View Article and Find Full Text PDFSimultaneous monitoring of creatinine and urea in diversified clinical samples based on SERS-active PDMS-flower-like ZIF-67@Ag nanoparticles.
Anal Chim Acta
May 2025
Department of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, PR China. Electronic address:
The sensitive, efficient, and simultaneous assay of creatinine and urea in different body fluid is crucial for the daily detection and treatment of chronic kidney disease. Here, we exploited a versatile composite surface enhanced Raman scattering (SERS) substrate of polydimethylsiloxane (PDMS)-flower-like ZIF-67@Ag nanoparticles (NPs) based on simple in-situ growth and ion sputtering strategies. The plasmonic Ag NPs assembled on the three-dimensional anisotropic ZIF-67 matrix, facilitating numerous resonant electromagnetic "hotspots".
View Article and Find Full Text PDFFabrication of tailored imprinted layer and cladded layer on magnetic nanomaterials with enhanced specificity for recognition of PFOS.
Anal Chim Acta
May 2025
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. Electronic address:
Background: Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant with significant risks to ecosystems and human health. Magnetic molecularly imprinted polymers (MIPs) provide a promising solution for selectively extracting PFOS from contaminated water. However, while bifunctional monomer imprinting improves the imprinting effect by introducing diverse functional groups, it can also increase non-specific adsorption.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!