1,8-Naphthyridone-3-carboxyl is the core structure of several on-market antibacterial drugs. It has prompted significant interest from the synthetic community. Here, we report a practical synthesis of diversely functionalized 1,8-naphthyridone-3-carboxylic acid derivatives starting from readily available and inexpensive nicotinic acid derivatives. All key steps have been optimized. Furthermore, the usefulness of this protocol has been exemplified by the first synthesis of amfonelic acid.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/acs.joc.4c00415 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!