Analysis of Effect of Melatonin on Postoperative Sensory Nerve Recovery Following Open Reduction and Internal Fixation of Anterior Mandible Fractures: A Prospective Randomized Control Trial.

Purpose: Open reduction and internal fixation (ORIF) of the anterior mandibular fractures are commonly associated with mental nerve paraesthesia. This study evaluates the efficacy of melatonin on postoperative sensory functional recovery and pain following surgical treatment of anterior mandibular fractures.

Methods: Forty patients were randomly allocated to two groups: Group I-melatonin, and Group II-control group. Postoperative neurosensory recovery was evaluated both subjectively and objectively at 1-week, 1-month, and 3-month intervals. The pain was assessed during the immediate postoperative period, postoperative days 1, 2, 3, and 7 using a visual analog scale. Statistical significance was set at value < 0.05.

Results: The statistically significant difference was noticed in both subjective and objective recovery of sensory nerve function at 1-month follow-up. All patients in the melatonin group showed complete recovery of nerve function as compared to the control group where 10% of patients showed limited recovery.

Conclusion: Neurosensory recovery following ORIF of mandibular fractures was better in the melatonin group as compared to the control group and therefore the perioperative administration of 10 mg. Melatonin can be recommended for quicker and better nerve recovery in the anterior mandibular fractures requiring close manipulation of the mental nerve during treatment.