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Traumatic ulcerative granuloma with stromal eosinophilia mimicking a squamous cell carcinoma. | LitMetric

Traumatic ulcerative granuloma with stromal eosinophilia mimicking a squamous cell carcinoma.

J Clin Exp Dent

DDS, MSc, PhD. Department of Pathology, Federal University of Santa Catarina, Health Sciences Center, Florianópolis, Santa Catarina, Brazil.

Published: March 2024

AI Article Synopsis

  • TUGSE is a rare oral mucosa lesion resembling oral carcinoma, often resulting from trauma, such as ill-fitting dentures, as seen in a 59-year-old male patient with a painful tongue ulcer.
  • An incisional biopsy showed eosinophil-rich inflammation and specific immune cell markers, leading to a final diagnosis of TUGSE after ruling out more serious conditions like oral squamous cell carcinoma.
  • The patient's symptoms improved within three weeks after removing the irritant, highlighting the importance of accurate diagnoses to avoid unnecessary surgeries for similar ulcerative lesions.

Article Abstract

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare lesion of a traumatic-reactive nature of the oral mucosa that can clinically mimic an oral carcinoma. A 59-year-old male patient presented painful ulceration with indurated margins on the base of the tongue, extending to the floor of the mouth. The use of ill-fitting denture hurting the mucosa of the region was reported by the patient. The evolution time was 45 days. The presumptive diagnoses were oral squamous cell carcinoma and chronic ulcer. An incisional biopsy revealed an ulceration associated with an eosinophil-rich inflammatory infiltrate and a bed of proliferating histiocyte-like cells in either diffuse or fasciculate arrangement. There was diffuse immunopositivity for CD3, but focal for CD68 and α-SMA, and negativity for CD30. The final diagnosis was TUGSE. The use of the ill-fitting dental prosthesis was suspended and the lesion had complete spontaneous remission three weeks later. TUGSE is an uncommon traumatic self-limiting lesion that must be included in the differential diagnosis of ulcerative lesions resembling oral cancer. The correlation of clinical and histopathological findings is pivotal for a proper diagnosis, avoiding unnecessary aggressive surgical approaches. Oral ulcer, eosinophilia, immunohistochemical, differential diagnosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11003278PMC
http://dx.doi.org/10.4317/jced.61322DOI Listing

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