Porcine respiratory coronavirus (PRCV) was initially detected in Europe, and later in the United States of America (US), in the 1980s. In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented. These sequences were aligned with nine other PRCV sequences from Europe and the US, and 43 TGEV sequences. Following alignment of the PRCV sequences, it was apparent that multiple amino acid variations in the structural proteins were distinct between the European and US strains. The alignments were used to build phylogenetic trees to infer the evolutionary relationships between the strains. In these trees, the European PRCV strains clustered as a separate group, whereas the US strains of PRCV all clustered with TGEVs.
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High-throughput screening for respiratory pathogens within pigs in Denmark; analysis of circulating porcine respiratory coronaviruses and their association with other pathogens.
Virus Res
December 2024
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 88 1870 Frederiksberg, Denmark. Electronic address:
Article Synopsis
- Porcine respiratory coronavirus (PRCV) primarily causes mild respiratory issues in pigs, but it can lead to more serious conditions under certain circumstances.
- A study in Denmark found that around 75% of recent pig blood samples contained antibodies against PRCV, indicating a high prevalence.
- Genetic analysis showed that the current PRCV strains in Denmark are related to earlier European strains and suggest the need for further research on their impact on pig health.
First report of transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) in pigs from Poland.
BMC Vet Res
November 2024
National Veterinary Research Institute, Al. Partyzantów 57, Puławy, 24-100, Poland.
Article Synopsis
- Porcine transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) are swine coronaviruses without prior prevalence or genetic data from Poland until this study.
- The research tested 828 serum samples for antibodies and 277 nasal swabs/221 stool samples for viral RNA, revealing a 2.2% seroprevalence for TGEV and 12.2% for PRCV, with PRCV RNA found in 6.22% of samples.
- Genetic analysis showed Polish PRCV strains were more closely related to European and Korean strains, with distinct deletions that suggest multiple origins and unique evolutionary traits.
Prevalence and Genetic Characterization of Porcine Respiratory Coronavirus in Korean Pig Farms.
Animals (Basel)
June 2024
Institute for Veterinary Biomedical Science, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Article Synopsis
- Porcine respiratory coronavirus (PRCV) is prevalent in Korean pig farms, with a farm-level seroprevalence of 68.6%, indicating ongoing circulation of the virus since its identification in 1997.
- In samples from seropositive farms, PRCV RNA was detected in 28.3% of oral fluid samples, while no TGEV RNA was found, highlighting the focus on PRCV.
- Genetic analysis of Korean PRCV strains revealed high homology among them and suggested a European origin due to a significant amino acid deletion, indicating that Korean PRCVs have evolved independently from American strains.
Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses.
Virology
July 2024
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg, Denmark. Electronic address:
Porcine respiratory coronavirus (PRCV) was initially detected in Europe, and later in the United States of America (US), in the 1980s. In this study we obtained and compared PRCV sequences from Europe and the US, and investigated how these are related to transmissible gastroenteritis virus (TGEV) sequences. The whole genome sequences of Danish (1/90-DK), Italian (PRCV15087/12 III NPTV Parma), and Belgian PRCV (91V44) strains are presented.
View Article and Find Full Text PDFPorcine Respiratory Coronavirus (PRCV): Isolation and Characterization of a Variant PRCV from USA Pigs.
Pathogens
August 2023
Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011, USA.
Porcine respiratory coronavirus (PRCV), a mutant of the transmissible gastroenteritis virus (TGEV), was first reported in Belgium in 1984. PRCV typically replicates and induces mild lesions in the respiratory tract, distinct from the enteric tropism of TGEV. In the past 30 years, PRCV has rarely been studied, and most cited information is on traditional isolates obtained during the 1980s and 1990s.
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