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Mesenteric vein thrombosis: A case report.
Int J Surg Case Rep
July 2024
General Surgery Department, Somali Sudanese Specialized Hospital, Mogadishu, Somalia.
Introduction: The most frequent location of thrombosis development in acute mesenteric venous thrombosis is the superior mesenteric vein. It is an uncommon but potentially fatal condition. Patients with underlying medical conditions that interfere with the Virchow Triad hypercoagulability, stasis, and endothelial injury are more likely to experience it.
View Article and Find Full Text PDFCyclooxygenase-2 as a therapeutic target against human breast cancer: A comprehensive review.
WIREs Mech Dis
May 2023
Tumor Biology, ICMR-National Institute of Pathology, New Delhi, India.
Cyclooxygenase-2 (COX-2) is a key aspect of the physiology and pathogenesis of various cancer types. Overexpression of this enzyme is responsible for the elevated prostaglandin production and characteristic feature of breast cancer. Inhibition of COX-2 derived prostanoids facilitates anti-inflammatory, analgesic, and antipyretic effects of non-steroid anti-inflammation drugs.
View Article and Find Full Text PDFNuclear Receptors in Ovarian Function.
Adv Exp Med Biol
September 2022
Robinson Research Institute, School of Biomedicine, Faculty of Health & Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
The ovary undergoes cycles of hormone production that regulate physiological changes necessary for folliculogenesis, ovulation and luteinisation, ultimately contributing to female reproductive success. Crucial to these biological processes is stage-specific nuclear receptor signalling. While the transcriptional regulatory roles of steroid receptors in female fertility and especially ovarian functions have long been documented, non-steroid receptors also play an important part in regulating gene expression at various stages of ovarian development.
View Article and Find Full Text PDFSynthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action.
Bioorg Med Chem Lett
August 2022
Department of Biotechnology, Faculty of Arts and Science, Mersin University, TR-33440, Mersin, Turkey; Mersin University Biotechnology Research and Application Center, Mersin University, TR-33440, Mersin, Turkey. Electronic address:
In this study, six new 1,4-disubstituted bis-1,2,3-triazole compounds, N,N'-(1,2-phenylene)bis(2-(4-R-1H-1,2,3-triazol-1-yl)acetamide), were synthesized with high yield (88-96 %) by using click chemistry and their molecular structures were characterized by using NMR, FT-IR, HRMS and elemental analysis techniques. Previous studies suggest anti-inflammatory and analgesic activities for different 1,2,3-triazole derivatives and in the light of those studies we aimed to examine these novel derivatives immunomodulatory activities on the mammalian macrophages. Pro-inflammatory cytokines (TNF, IL6, GMCSF and IL12p40) secretion levels were tested in the presence of bis-1,2,3-triazole compounds when the macrophages were activated with LPS.
View Article and Find Full Text PDFIn vitro and clinical evaluation of umbilical cord-derived mesenchymal stromal cell-conditioned media for hair regeneration.
J Cosmet Dermatol
February 2022
Clinical R & D, OCT Therapies and Research Pvt Ltd, Mumbai, India.
Background: The field of regenerative medicine may present a non-drug, non-steroid, and non-invasive alternative toward addressing male and female pattern hair loss, a global concern.
Objective: The aim was to carry out the in vitro and in vivo safety and efficacy evaluation of human umbilical cord-derived mesenchymal stromal cell-conditioned media (MSC-CM) for hair regeneration.
Methods: Various in vitro parameters were used to estimate the consistency across various batches of MSC-CM.
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