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Capturing Chromatin Organization by MNase-seq and ATAC-seq.
Methods Mol Biol
January 2025
Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.
Hox genes play a pivotal role during development. Their expression is tightly controlled in a spatiotemporal manner, ensuring that specific body structures develop at the correct locations and times during development. Various genomics approaches have been used to capture temporal and dynamic regulation of Hox gene expression at the nucleosome/chromatin level.
View Article and Find Full Text PDFTargeted plasma metabolomics reveals potential biomarkers of the elderly with mild cognitive impairment in Qingdao rural area.
Front Aging Neurosci
December 2024
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, Shandong, China.
Introduction: Previous research has suggested a link between the onset of Alzheimer's disease (AD) and metabolic disorder; however, the findings have been inconsistent. To date, the majority of metabolomics studies have focused on AD, resulting in a relative paucity of research on early-stage conditions such as mild cognitive impairment (MCI) underexplored. In this study, we employed a comprehensive platform for the early screening of individuals with MCI using high-throughput targeted metabolomics.
View Article and Find Full Text PDFHand hygiene, knowledge and training motivational drives: findings from a survey in a university hospital.
Front Public Health
January 2025
Section of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
This study assessed healthcare workers' (HCWs) knowledge and adherence to hand hygiene principles in a large Italian university hospital, focusing on identifying knowledge gaps and evaluating training effectiveness. A specifically designed 17-item questionnaire, based on the World Health Organization (WHO) Hand Hygiene Knowledge Questionnaire, was used to measure theoretical knowledge, the role of training, and the impact of experience. The survey had an 8% participation rate (542 responses from a total of 6,749 HCWs), with higher responses among nurses and doctors.
View Article and Find Full Text PDF[Paying attention to problems and countermeasures in intermittent exotropia surgery].
Zhonghua Yan Ke Za Zhi
January 2025
Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing210029, China.
Intermittent exotropia (IXT) is the most common type of strabismus, with surgical interventions standing as its main therapeutic modality. In recent years, with the rapid development of the strabismus and pediatric ophthalmology subspecialties, surgical correction for IXT has become a routine practice across numerous institutions in China. However, the surgical success rate is not high and tends to decline with longer follow-up periods.
View Article and Find Full Text PDFComparative evaluation of intraoral scanners and a spectrophotometer for percent correct shade identification in clinical dentistry.
Clin Oral Investig
January 2025
Center for Dental Medicine, Department of Operative Dentistry and Periodontology, Faculty of Medicine and Medical Center, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg im Breisgau, Germany.
Objectives: The study aimed to assess the percent correct shade identification of four intraoral scanners (IOS) and a spectrophotometer, focusing on how reliably each device selects the correct tooth shade compared to a visual observer's selection. The research question addresses how much clinicians can trust the device-selected shade without visual verification.
Materials And Methods: Sixteen participants with natural, unrestored teeth were included.
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