Environmental airborne antigens are central to the development of allergic asthma, but the cellular processes that trigger disease remain incompletely understood. In this report, Schmitt et al. (https://doi.org/10.1084/jem.20231236) identify TNF-like protein 1A (TL1A) as an epithelial alarmin constitutively expressed by a subset of lung epithelial cells, which is released in response to airborne microbial challenge and synergizes with IL-33 to drive allergic disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11010314 | PMC |
| http://dx.doi.org/10.1084/jem.20240389 | DOI Listing |
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