A water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds is reported for the synthesis of spiro[chromeno[4,3-]cyclopenta[]pyridine-7,3'-indoline]trione and the spiro[chromeno[4,3-]quinoline 7,3'-indoline]trione. Up to 27 different spirooxindole derivatives were synthesized by this method. The bioactivity of these spirooxindole derivatives was evaluated and they were found to show antifungal activity against , , , and .
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Recent advances in the reactions of isatin-derived MBH carbonates for the synthesis of spirooxindoles.
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