AI Article Synopsis
- The study investigates potential biomarkers for ST-segment elevation myocardial infarction (STEMI), a major cause of cardiovascular mortality.
- A bioinformatics analysis identified 133 differentially expressed genes (DEGs) that highlight the roles of inflammation, metabolism, and immunity in the progression from stable coronary artery disease (SCAD) to STEMI.
- Specific genes MS4A3, KLRC4, KLRD1, AQP9, and CD14 showed promise as candidate biomarkers due to their high sensitivity and specificity in predicting STEMI.
Article Abstract
Background: ST-segment elevation myocardial infarction (STEMI) is one of the leading causes of fatal cardiovascular diseases, which have been the prime cause of mortality worldwide. Diagnosis in the early phase would benefit clinical intervention and prognosis, but the exploration of the biomarkers of STEMI is still lacking.
Objectives: In this study, we conducted a bioinformatics analysis to identify potential crucial biomarkers in the progress of STEMI.
Methods: We obtained GSE59867 for STEMI and stable coronary artery disease (SCAD) patients. Differentially expressed genes (DEGs) were screened with the threshold of |log2fold change| > 0.5 and p <0.05. Based on these genes, we conducted enrichment analysis to explore the potential relevance between genes and to screen hub genes. Subsequently, hub genes were analyzed to detect related miRNAs and DAVID to detect transcription factors for further analysis. Finally, GSE62646 was utilized to assess DEGs specificity, with genes demonstrating AUC results exceeding 75%, indicating their potential as candidate biomarkers.
Results: 133 DEGs between SCAD and STEMI were obtained. Then, the PPI network of DEGs was constructed using String and Cytoscape, and further analysis determined hub genes and 6 molecular complexes. Functional enrichment analysis of the DEGs suggests that pathways related to inflammation, metabolism, and immunity play a pivotal role in the progression from SCAD to STEMI. Besides, related-miRNAs were predicted, has-miR-124, has-miR-130a/b, and has-miR-301a/b regulated the expression of the largest number of genes. Meanwhile, Transcription factors analysis indicate that EVI1, AML1, GATA1, and PPARG are the most enriched gene. Finally, ROC curves demonstrate that MS4A3, KLRC4, KLRD1, AQP9, and CD14 exhibit both high sensitivity and specificity in predicting STEMI.
Conclusions: This study revealed that immunity, metabolism, and inflammation are involved in the development of STEMI derived from SCAD, and 6 genes, including MS4A3, KLRC4, KLRD1, AQP9, CD14, and CCR1, could be employed as candidate biomarkers to STEMI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.36660/abc.20230462 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Knowledge domain and frontier trends of artificial intelligence applied in solid organ transplantation: A visualization analysis.
Int J Med Inform
December 2024
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Background: Solid organ transplantation (SOT) is vital for end-stage organ failure but faces challenges like organ shortage and rejection. Artificial intelligence (AI) offers potential to improve outcomes through better matching, success prediction, and automation. However, the evolution of AI in SOT research remains underexplored.
View Article and Find Full Text PDFMusculoskeletal Computed Tomography: How to Add Value When Reporting Adult Lower Limb Trauma.
J Comput Assist Tomogr
November 2024
Department of Trauma and Orthopaedics, University Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom.
Computed tomography plays an ever-increasing role in the management of fractures and dislocations due to its capability in efficiently providing multiplanar reformats and 3-dimensional volume rendered images. It can reveal findings that are occult on plain radiography and therefore allow for more accurate decision making with regard to fracture classification and management. Clinical radiologists play a critical role in facilitating the processing of imaging to provide adequate image reformats in the desired planes, producing 3 dimensional images but most crucially identifying pertinent findings, which will contribute between the selection of nonoperative and operative management and potentially influence surgical technique.
View Article and Find Full Text PDFEnhanced Anti-Interference Photoelectrochemical DNA Bioassay: Grafting a Peptide-Conjugated Hairpin DNA Probe on a COF-Based Photocathode.
ACS Sens
January 2025
Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Precise and sensitive analysis of specific DNA in actual human bodily fluids is crucial for the early diagnosis of major diseases and for a deeper understanding of DNA functions. Herein, by grafting a peptide-conjugated hairpin DNA probe to a covalent organic framework (COF)-based photocathode, a robust anti-interference photoelectrochemical (PEC) DNA bioassay was explored, which could specifically resist potential interference from nonspecific proteins and reducing species. Human immunodeficiency virus (HIV) DNA was used as the target DNA (tDNA) for the PEC DNA bioassay.
View Article and Find Full Text PDFSelf-Sufficient Electrochromic Solar Cells: Photovoltaic and Color Modulating Smart Windows.
ACS Appl Mater Interfaces
January 2025
Department of Physics, Indian Institute of Technology Indore, Simrol 453552, India.
Electronic devices cover a large subset of daily life gadgets which use power to run, hence increasing the load of the energy needs and indirectly impacting greenhouse gas emissions. Smart electrochromic windows provide a solution to this through remarkable energy saving by adjusting optical behavior depending on the environmental conditions. Since the electrochromic windows also need power to run, a self-powered electrochromic panel will be a better solution.
View Article and Find Full Text PDFFundamental constraints and questions from the study of martian meteorites and the need for returned samples.
Proc Natl Acad Sci U S A
January 2025
School of Geographical and Earth Sciences, Gregory Building, University of Glasgow, Glasgow G12 8QQ, Scotland.
Physical materials from planetary bodies are crucial for understanding fundamental processes that constrain the evolution of the solar system, as samples can be analyzed at high precision and accuracy in Earth-based laboratories. Mars is the only planet outside of Earth from which we possess samples in the form of meteorites. Martian meteorites (n > 350) have enabled constraints to be placed on various aspects of the red planet's formation and evolution, notably: that Mars accreted and differentiated rapidly; that the planet has a complex volatile element evolution; and that it has always been volcanically active with a rich and diverse magmatic history.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!