AI Article Synopsis
- Traditional Chinese medicine external prescriptions are effective for treating deep soft tissue injuries, but their impact is limited by dosage forms and application methods.
- A new hydrogel adjuvant was created using gallic acid, ε-poly-l-lysine, and oxidized hyaluronic acid, showing low hemolysis, strong antibacterial and antioxidant properties, and good biocompatibility.
- The hydrogel adjuvant enhances the effectiveness of traditional prescriptions without compromising their properties, suggesting a promising approach for combining traditional Chinese medicine with hydrogel technology for better clinical outcomes.
Article Abstract
Traditional Chinese medicine external prescriptions have displayed excellent clinical effects for treating deep soft tissue injuries. However, the effects cannot be fully utilized due to the limitations of their dosage forms and usage methods. It is still a challenge to develop a satisfactory adjuvant of traditional Chinese medicine external prescriptions. Herein, a hydrogel adjuvant was prepared based on gallic acid coupled ε-poly-l-lysine and partially oxidized hyaluronic acid. The resulting adjuvant shows great physicochemical properties, low hemolysis rate (still much less than 5% at 5 mg/mL), excellent antibacterial ability (about 95% at 2 mg/mL), strong antioxidant ability (1.687 ± 0.085 mmol FeSO/(g hydrogel) at 1 mg/mL), as well as outstanding biocompatibility. A clinically used Chinese medicine external preparation was selected as an example to investigate the effectiveness of the adjuvant in treating deep soft tissue injuries. The results show that the prescription can be evenly dispersed in the adjuvant. Moreover, the introduction of the prescription has not significantly changed these advanced properties of the adjuvant. Importantly, the hydrogel adjuvant significantly improves the effectiveness of the prescription in treating deep soft tissue injuries. This work offers an alternative approach to the development of a new-type adjuvant of Chinese medicine external preparations and also provides a new strategy for the combination of traditional Chinese medicine and hydrogel to treat clinical diseases.
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| http://dx.doi.org/10.1021/acsbiomaterials.4c00165 | DOI Listing |
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