AI Article Synopsis
- Diabetic neuropathy (DN) is a serious complication of diabetes, and chondroitin sulfate (CS) plays a significant role in its pathology, although its specific impact had not been previously studied.
- Researchers created mice with reduced CS levels (T1KO) and found that these diabetic mice were more resistant to DN compared to normal mice (wild-type).
- The study highlighted stable interactions between blood vessel cells (pericytes and endothelial cells) in T1KO mice, and suggested that lower CS levels may help mitigate DN by affecting signaling pathways related to inflammation and tissue repair.
Article Abstract
Diabetic neuropathy (DN) is a major complication of . Chondroitin sulfate (CS) is one of the most important extracellular matrix components and is known to interact with various diffusible factors; however, its role in DN pathology has not been examined. Therefore, we generated CSGalNAc-T1 knockout (T1KO) mice, in which CS levels were reduced. We demonstrated that diabetic T1KO mice were much more resistant to DN than diabetic wild-type (WT) mice. We also found that interactions between pericytes and vascular endothelial cells were more stable in T1KO mice. Among the RNA-seq results, we focused on the transforming growth factor β signaling pathway and found that the phosphorylation of Smad2/3 was less upregulated in T1KO mice than in WT mice under hyperglycemic conditions. Taken together, a reduction in CS level attenuates DN progression, indicating that CS is an important factor in DN pathogenesis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002665 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.109528 | DOI Listing |
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