Comparison of Different Antibiotic Medications on Microorganisms: An Original Research.

J Pharm Bioallied Sci

Rashtriya Kishore Swasthya Karyakram Consultant, District Medical and Health Office, Visakhapatnam, Andhra Pradesh, India.

Published: February 2024

AI Article Synopsis

  • The study investigates how common antibiotics affect pathogenic microorganisms in the mouth, focusing on both antibacterial and antifungal activities.
  • Various antibiotics, including Augmentin, Ceftriaxone, and Linezolid, were tested using the agar-well diffusion method to measure their effectiveness against specific microorganisms and Lactobacillus.
  • The results showed varying zones of inhibition based on antibiotic type and concentration, indicating the need for further research on antibiotic resistance mechanisms in these organisms.

Article Abstract

Introduction: The onset and maintenance of disease can be significantly influenced by the colonization of the mouth cavity by pathogenic microorganisms or by an imbalance of the physiological microbiome. Hence, in the current study, various commonly used antibiotics have been tested for their antibacterial and antifungal activity.

Materials And Methods: The current research was performed as an study. The commonly used antibiotics Augmentin (CV), Ceftriaxone-Cephalosporin (CF), and Linezolid were tested for the microorganisms, lactobacillus, and . The "Radius of Zone of Inhibition (mm)- RZI" after 24 and 48 h were tested by the agar-well diffusion method.

Results: For , the antibiotics tested were CV (5 μl and 2.5 μl), CF (5 μl and 2.5 μl), and Linezolid (5 μl and 2.5 μl). The results showed that the radius of the zone of inhibition was consistent for each antibiotic concentration, with a range of 0.8-1.4 mm at both time points. For Lactobacillus, the antibiotics tested were CV (5 μl and 2.5 μl), CF (5 μl and 2.5 μl), and Linezolid (5 μl and 2.5 μl). The results showed that the radius of the zone of inhibition varied between antibiotics and concentrations, with a range of 0.5-1.8 mm at both time points.

Conclusion: This study highlights antibiotics' antibacterial action against and Lactobacillus. The data imply that antibiotic efficacy varied by organism and drug concentration. These organisms' antibiotic resistance mechanisms and new antibiotic resistance methods need more study.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001070PMC
http://dx.doi.org/10.4103/jpbs.jpbs_471_23DOI Listing

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