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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11003800 | PMC |
| http://dx.doi.org/10.1055/a-2288-5076 | DOI Listing |
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Effect of fluoridated water on invasive NHS dental treatments for adults: the LOTUS retrospective cohort study and economic evaluation.
Public Health Res (Southampt)
May 2024
Division of Dentistry, The University of Manchester, Manchester, UK.
Background: Most water fluoridation studies were conducted on children before the widespread introduction of fluoride toothpastes. There is a lack of evidence that can be applied to contemporary populations, particularly adolescents and adults.
Objective: To pragmatically assess the clinical and cost effectiveness of water fluoridation for preventing dental treatment and improving oral health in a contemporary population of adults, using a natural experiment design.
Lebrikizumab Provides Rapid Clinical Responses Across All Eczema Area and Severity Index Body Regions and Clinical Signs in Adolescents and Adults with Moderate-to-Severe Atopic Dermatitis.
Dermatol Ther (Heidelb)
May 2024
Department of Dermatology, George Washington University School of Medicine and Health, Washington, DC, USA.
Article Synopsis
- Atopic dermatitis (AD) is a skin condition that can be difficult to treat in certain body areas; this study focused on how lebrikizumab impacts AD severity across different regions.
- In two clinical trials, lebrikizumab was administered every two weeks, and patients showed significant improvement in the Eczema Area and Severity Index (EASI) after 16 weeks compared to those given a placebo.
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Lotus sign: The lumen-apposing metal stent that failed to bloom.
Endoscopy
December 2024
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Aberrant Mannosylated and Highly Fucosylated Glycoepitopes of Prostatic Acid Phosphatase as Potential Ligands for Dendritic-Cell Specific ICAM-Grabbing Nonintegrin (DC-SIGN) in Human Seminal Plasma-A Step towards Explaining Idiopathic Infertility.
Biomolecules
December 2023
Department of Biochemistry and Immunochemistry, Division of Chemistry and Immunochemistry, Wroclaw Medical University, M. Skłodowskiej-Curie 48/50, 50-369 Wroclaw, Poland.
Semen prostatic acid phosphatase (PAP) has been proposed as an endogenous ligand for dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), which plays a critical immuno-modulating role in maintaining homeostasis in the female reproductive tracts. In the current study, we assumed that semen PAP bears a set of fucosylated and mannosylated glycans, which may mediate the efficient binding of PAP to DC-SIGN. To investigate this hypothesis, we developed ELISA assays using and lectins capable of binding mannose-containing glycans or LewisX and LewisY motifs, respectively.
View Article and Find Full Text PDFTopical cyclosporine versus allergen specific immunotherapy in perennial allergic conjunctivitis.
Int Ophthalmol
July 2023
Division of Allergy and Immunology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Purpose: Symptom control in the long-term with less side effects is important in perennial allergic conjunctivitis, since would improve quality of life. This study aimed to assess the clinical efficacies of topical cyclosporin A and subcutaneous allergen immunotherapy (SCIT) in terms of sign control in perennial allergic conjunctivitis.
Methods: This retrospective study included 20 adult patients with perennial allergic conjunctivitis and confirmed sensitization to house dust mites with skin prick test.
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