AI Article Synopsis
- Abnormal epigenetic modifications, particularly DNA hypomethylation, can lead to cancerous changes in gastrointestinal (GI) cells, which represent 20% of all cancers globally.
- CpG methylation and promoter hypermethylation serve as important biomarkers for various malignancies and can disrupt key processes like cell cycle control and DNA repair in GI cancers.
- By studying DNA methylation patterns in GI cancers, researchers aim to enhance targeted treatments and discover new diagnostic tools.
Article Abstract
Abnormalities in epigenetic modifications can cause malignant transformations in cells, leading to cancers of the gastrointestinal (GI) tract, which accounts for 20% of all cancers worldwide. Among the epigenetic alterations, DNA hypomethylation is associated with genomic instability. In addition, CpG methylation and promoter hypermethylation have been recognized as biomarkers for different malignancies. In GI cancers, epigenetic alterations affect genes responsible for cell cycle control, DNA repair, apoptosis, and tumorigenic-specific signaling pathways. Understanding the pattern of alterations in DNA methylation in GI cancers could help scientists discover new molecular-based pharmaceutical treatments. This study highlights alterations in DNA methylation in GI cancers. Understanding epigenetic differences among GI cancers may improve targeted therapies and lead to the discovery of new diagnostic biomarkers.
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| http://dx.doi.org/10.1016/j.ejphar.2024.176563 | DOI Listing |
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