The viscous glycocalyx of mammalian cells, composed of glucosaminoglycans, glycolipids, and glycoproteins, "sugar coat" the outer plasma membrane. In this issue of Developmental Cell, Le et al. (2024) show that the glycocalyx is removed from apoptotic blebs via disassembly of the cortical cytoskeleton, exposing the "eat-me" signals necessary for efferocytosis.
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Water-glycan interactions drive the SARS-CoV-2 spike dynamics: insights into glycan-gate control and camouflage mechanisms.
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August 2024
Laboratoire de Chimie Théorique, Sorbonne Université, UMR 7616 CNRS 75005 Paris France
To develop therapeutic strategies against COVID-19, we introduce a high-resolution all-atom polarizable model capturing many-body effects of protein, glycan, solvent, and membrane components in SARS-CoV-2 spike protein open and closed states. Employing μs-long molecular dynamics simulations powered by high-performance cloud-computing and unsupervised density-driven adaptive sampling, we investigated the differences in bulk-solvent-glycan and protein-solvent-glycan interfaces between these states. We unraveled a sophisticated solvent-glycan polarization interaction network involving the N165/N343 glycan-gate patterns that provide structural support for the open state and identified key water molecules that could potentially be targeted to destabilize this configuration.
View Article and Find Full Text PDFNo need to "sugar coat": Removing glycocalyx on apoptotic blebs promotes phagocytosis.
Dev Cell
April 2024
Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, Saint Louis, MO, USA; Department of Biomedical Molecular Biology, Ghent University, and the Inflammation Research Center, VIB, Ghent, Belgium. Electronic address:
The viscous glycocalyx of mammalian cells, composed of glucosaminoglycans, glycolipids, and glycoproteins, "sugar coat" the outer plasma membrane. In this issue of Developmental Cell, Le et al. (2024) show that the glycocalyx is removed from apoptotic blebs via disassembly of the cortical cytoskeleton, exposing the "eat-me" signals necessary for efferocytosis.
View Article and Find Full Text PDFDon't sugar coat it: The independent and synergistic impacts of obesity and gestational diabetes on placental parameters.
J Physiol
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School of Public Health, Physiotherapy and Sports Science, Conway Institute, Institute of Food and Health, University College Dublin, Dublin, Ireland.
Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments.
Biochem Soc Trans
November 2021
Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
The importance of vaccine-induced protection was repeatedly demonstrated over the last three decades and emphasized during the recent COVID-19 pandemic as the safest and most effective way of preventing infectious diseases. Vaccines have controlled, and in some cases, eradicated global viral and bacterial infections with high efficiency and at a relatively low cost. Carbohydrates form the capsular sugar coat that surrounds the outer surface of human pathogenic bacteria.
View Article and Find Full Text PDFDon't sugar coat the COVID (only the vasculature).
Biomed J
October 2020
University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark. Electronic address:
This issue of the Biomedical Journal acquaints us with the compelling hypothesis that the vascular glycocalyx lies at the intersection of severe COVID-19 risk factors and damages, and the ways used by artificial intelligence to predict interactions between SARS-CoV-2 and human proteins. Furthermore, we explore the antiviral potential of valinomycin and the long list of COVID-19-related clinical trials, and learn how (not) to fix a broken femoral head. Last but not least, we get to enjoy the tale of the cellular oxygen-sensing system as well as the role of the host complement system during Leptospira infection, and learn that SARS-CoV-2 can sometimes come with a pathogenic plus one.
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