AI Article Synopsis
- The study investigates the link between exposure to chlorinated paraffins (CPs), a type of persistent organic pollutant, and the prevalence of allergic diseases in children and adolescents in the Pearl River Delta region of China.
- A survey with 131,304 participants highlighted that increased levels of CPs in particulate matter are significantly associated with allergic rhinitis, atopic eczema, and allergic conjunctivitis, showing specific odds ratios for each condition.
- The research suggests that overweight and obese individuals may be at an even higher risk for these allergic diseases; however, further studies are necessary to confirm these findings and explore the underlying mechanisms.
Article Abstract
Contaminants may induce immune response polarization, leading to immune diseases, such as allergic diseases. Evidence concerning the effects of chlorinated paraffins (CPs), an emerging persistent organic pollutant, on immune system is scarce, particularly for epidemiological evidence. This study explores the association between CPs exposure and allergic diseases (allergic rhinitis, atopic eczema, and allergic conjunctivitis) in children and adolescents in the Pearl River Delta (PRD) in China. Herein, 131,304 children and adolescents from primary and secondary schools in the PRD were included and completed the questionnaire survey. The particulate matter (PM) samples were collected in the PRD and the PM-bound CP concentrations were analyzed. In the multivarious adjustment mixed effect model (MEM), an IQR increase in ∑CPs was significantly associated with allergic diseases (rhinitis, eczema, and conjunctivitis) with the estimated odds ratios (ORs) for 1.11 (95% CI: 1.10, 1.13), 1.17 (95% CI: 1.15, 1.19), and 1.82 (95% CI: 1.76, 1.88), respectively. Interaction analysis indicated that overweight and obese individuals might have greater risk. Similar effect estimates were observed in several sensitivity analyses. This study provided epidemiological evidence on the immunotoxicity of CPs. More studies to confirm our findings and investigate mechanisms are needed.
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| http://dx.doi.org/10.1016/j.jhazmat.2024.134226 | DOI Listing |
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