Desvenlafaxine (DES) in conventional dosage forms shows initial burst release after oral administration, leading to exaggeration of its side effects. These side effects can be overcome by a sustained-release dosage form using the chemically inert, low-melting-point lipid Compritol 888 ATO, as it reduces initial burst release. The potential of DES-loaded solid lipid nanoparticles (DES-SLNs) synthesized by ultrasonication-assisted hot-melt encapsulation to modify the release of DES was investigated. The entrapment efficiency of DES-SLNs was 65.90% with the release profile showing a sustained-release behavior achieving 81% cumulative release within 16 h without initial burst release. DES-SLNs are a potential carrier for sustained release of water-soluble antidepressant drugs such as DES.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221374 | PMC |
| http://dx.doi.org/10.2217/nnm-2023-0229 | DOI Listing |
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