Background: Despite a successful repair of tetralogy of Fallot (rToF) in childhood, residual lesions are common and can contribute to impaired exercise capacity. Although both cycle ergometer and treadmill protocols are often used interchangeably these approaches have not been directly compared. In this study we examined cardiopulmonary exercise test (CPET) measurements in rToF.
Methods: Inclusion criteria were clinically stable rToF patients able to perform a cardiac magnetic resonance imaging (CMR) and two CPET studies, one on the treadmill (incremental Bruce protocol) and one on the cycle ergometer (ramped protocol), within 12 months. Demographic, surgical and clinical data; functional class; QRS duration; CMR measures; CPET data and international physical activity questionnaire (IPAQ) scores of patients were collected.
Results: Fifty-seven patients were enrolled (53% male, 20.5 ± 7.8 years at CPET). CMR measurements included a right ventricle (RV) end-diastolic volume index of 119 ± 22 mL/m, a RV ejection fraction (EF) of 55 ± 6% and a left ventricular (LV) EF of 56 ± 5%. Peak oxygen consumption (VO)/Kg (25.5 ± 5.5 vs. 31.7 ± 6.9; < 0.0001), VO at anaerobic threshold (AT) (15.3 ± 3.9 vs. 22.0 ± 4.5; < 0.0001), peak O pulse (10.6 ± 3.0 vs. 12.1± 3.4; = 0.0061) and oxygen uptake efficiency slope (OUES) (1932.2 ± 623.6 vs. 2292.0 ± 639.4; < 0.001) were significantly lower on the cycle ergometer compared with the treadmill, differently from ventilatory efficiency (VE/VCO) max which was significantly higher on the cycle ergometer (32.2 ± 4.5 vs. 30.4 ± 5.4; < 0.001). Only the VE/VCO slope at the respiratory compensation point (RCP) was similar between the two methodologies ( = 0.150).
Conclusions: The majority of CPET measurements differed according to the modality of testing, with the exception being the VE/VCO slope at RCP. Our data suggest that CPET parameters should be interpreted according to test type; however, these findings should be validated in larger populations and in a variety of institutions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932302 | PMC |
| http://dx.doi.org/10.3390/jcm13051192 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of a hands-free vascular ultrasound probe holder in active and inactive limbs during cycling exercise.
J Appl Physiol (1985)
January 2025
Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Canada.
Measurement of blood flow during exercise is crucial for understanding physiological responses and performance outcomes. However, traditional methods are often invasive, costly, or require substantial training, limiting widespread research in this area. This study introduces the innovative use of limb-affixed ultrasound probe holders for vascular imaging during exercise to overcome these challenges.
View Article and Find Full Text PDFAn open data for imaging acute aerobic exercise effects on brain and mind in emerging adulthood.
Sci Data
December 2024
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.
How emerging adulthood, a period particularly susceptible to the onset of mental disorders, responds to acute aerobic exercise effects on mood and brain remains an open question. A challenge in addressing this question is the scarcity of open data derived from scientific intervention paradigms. We recruited 83 healthy volunteers aged 17 to 24, who were randomly assigned to either an exercise group or a control group.
View Article and Find Full Text PDFImpact of exercise and fasting on mitochondrial regulators in human muscle.
Transl Exerc Biomed
September 2024
School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Objectives: To investigate the impact of acute energetic stress (acute HIIE and fasting) on , , , , and in human skeletal muscle.
Methods: The current study performed secondary analyses using muscle biopsy samples from two previously published studies: study 1) leg muscle biopsies from nine men and eight women were obtained pre and 3 h following acute high-intensity interval cycling exercise (HIIE); study 2) leg muscle biopsies were obtained from nine men pre-, during, and post-an 8 h fast with or without 2 h of arm ergometer exercise. RT-PCR was performed on samples from each study to determine the mRNA expression of , , , , and .
Prehabilitation Exercise Training to Target Improved Muscle Strength in Pretransplant Patients Diagnosed With Multiple Myeloma: Protocol for a Pilot Randomized Controlled Trial.
JMIR Res Protoc
December 2024
Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.
Background: Muscle mass and strength are severely compromised in patients diagnosed with multiple myeloma, such that the risk of poor overall survival increases as the prevalence of low muscle mass, also known as sarcopenia, increases. Additionally, at the time of autologous stem cell transplant (ASCT), 51% of patients experience low muscle mass and strength, which can prolong hospitalization and lead to increased risk of obesity, insulin resistance, lowered physical function, and poor quality of life.
Objective: The PROTECT (Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation) trial will examine the preliminary effects of digitally supervised prehabilitative aerobic and resistance exercise on muscle strength in patients with multiple myeloma scheduled for ASCT.
Association of cardiorespiratory fitness with the incidence and progression trajectory of cardiometabolic multimorbidity.
Br J Sports Med
December 2024
School of Public Health, Tianjin Medical University, Tianjin, China
Objectives: This study examined the relationship of cardiorespiratory fitness (CRF) in the transition from healthy status to first cardiometabolic disease, subsequent cardiometabolic multimorbidity and further to death.
Methods: We used data from the UK Biobank of 47 484 participants without cardiometabolic diseases at baseline. CRF was assessed via a 6 min incremental ramp cycle ergometer test and expressed in metabolic equivalent of tasks (METs, 1 MET=3.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!