AI Article Synopsis
- The text discusses a specific bacterium that can thrive in stressful conditions and switch between being a soil bacterium and a pathogen in mammals.
- It emphasizes the importance of two-component signaling systems (TCSs), which help the bacterium sense environmental changes and respond by activating certain genes.
- The review highlights the challenges in identifying the exact stimuli that trigger TCS responses and points to ongoing research into the gene networks linked to these systems, which may reveal useful insights into stress resistance and pathogenesis.
Article Abstract
is well recognized for both its broad resistance to stress conditions and its ability to transition from a soil bacterium to an intracellular pathogen of mammalian hosts. The bacterium's impressive ability to adapt to changing environments and conditions requires the rapid sensing of environmental cues and the coordinated response of gene products that enable bacterial growth and survival. Two-component signaling systems (TCSs) have been long recognized for their ability to detect environmental stimuli and transmit those signals into transcriptional responses; however, often the precise nature of the stimulus triggering TCS responses can be challenging to define. has up to 16 TCSs that have been recognized based on homology and included in this list are several whose functions remain poorly described. This review highlights the current understanding of the breadth and scope of TCS as relates to stress resistance and pathogenesis. Precise signals still often remain elusive, but the gene networks associated with TCSs are providing clues into possible functions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11003226 | PMC |
| http://dx.doi.org/10.1128/iai.00345-23 | DOI Listing |
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Article Synopsis
- Signal transduction is key for communication and response in microbial communities, allowing them to adapt to environmental changes and establish structures for collective behaviors.
- Microbial communication occurs through methods like quorum sensing, biofilm formation, and chemotaxis, which help coordinate activities, enhance resource use, and improve resilience against stress.
- Understanding these signaling processes, especially in synthetic microbial consortia, has important implications for biotechnology, including biosensors, biodegradation, and waste management.
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