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Circular RNAs Mediate the Effects of Dietary Tryptophan on the Transformation of Muscle Fiber Types in Weaned Piglets. | LitMetric

Circular RNAs Mediate the Effects of Dietary Tryptophan on the Transformation of Muscle Fiber Types in Weaned Piglets.

J Agric Food Chem

Laboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.

Published: April 2024

AI Article Synopsis

  • The study investigates how dietary tryptophan (Trp) affects the growth and muscle fiber development of weaned piglets, comparing a low (0.14%) and high (0.35%) Trp diet over 28 days.
  • Piglets on the high Trp diet showed notable improvements in growth and an increase in fast muscle fibers.
  • Transcriptome sequencing identified key circular RNAs (circRNAs) that play a role in muscle fiber transformation by regulating related genes through specific microRNAs, enhancing our understanding of piglet muscle development.

Article Abstract

The nutritional composition of the diet significantly impacts the overall growth and development of weaned piglets. The current study aimed to explore the effects and underlying mechanisms of dietary tryptophan consumption on muscle fiber type transformation during the weaning period. Thirty weaned piglets with an average body weight of 6.12 ± 0.16 kg were randomly divided into control (CON, 0.14% Trp diet) and high Trp (HT, 0.35% Trp) groups and maintained on the respective diet for 28 days. The HT group of weaned piglets exhibited highly significant improvements in growth performance and an increased proportion of fast muscle fibers. Transcriptome sequencing revealed the potential contribution of differentially expressed circular RNAs toward the transformation of myofiber types in piglets and toward the regulation of expression of related genes by targeting the microRNAs, miR-34c and miR-182, to further regulate myofiber transformation. In addition, 145 DE circRNAs were identified as potentially protein-encoding, with the encoded proteins associated with a myofiber type transformation. In conclusion, the current study greatly advances and refines our current understanding of the regulatory networks associated with piglet muscle development and myofiber type transformation and also contributes to the optimization of piglet diet formulation.

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Source
http://dx.doi.org/10.1021/acs.jafc.4c00762DOI Listing

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