Charge Injection Enhancement Comparisons of Iridium Oxide Microelectrodes and Using a Portable Neurostimulator.

Microelectrodes are desired to deliver more charges to neural tissues while under electrochemical safety limits. Applying anodic bias potential during neurostimulation is a known technique for charge enhancement. Here, we investigated the levels of charge enhancement with anodic bias potential and using a custom-designed portable neurostimulator. We immersed our custom microelectrode probe in saline and measured voltage transients in response to constant current stimulation with and without a 500 mV anodic bias potential. We then inserted the same microelectrode probe into the primary motor cortex of the rat brain and measured voltage transients with the same electronics. Results showed that the charge injection capacity of the activated iridium oxide microelectrode site (with 2000 μm geometric surface areas (GSAs)) increased by the use of the anodic bias potentials in both and : from 10 nC/phase to 32 nC/phase for 200 μs pulse widths, and from 2 nC/phase to 8 nC/phase, respectively. Thus, the order of charge injection capacities of the four cases tested in this study is as follows (from the lowest to the highest): without anodic bias, with anodic bias, without anodic bias, and with anodic bias. This work also validated use of our new portable neurostimulator which received stimulation waveforms wirelessly.